| Tag | Content |
|---|
| CPLM ID | CPLM-021098 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ras-specific guanine nucleotide-releasing factor RalGPS2 |
Protein Synonyms/Alias | Ral GEF with PH domain and SH3-binding motif 2; RalA exchange factor RalGPS2 |
Gene Name | Ralgps2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 478 | LRRKTLLKEGKKPTV | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion. |
Sequence Annotation | DOMAIN 49 287 Ras-GEF.
DOMAIN 464 576 PH.
REGION 466 590 Required for stimulation of nucleotide
MOTIF 331 334 PXXP.
MOD_RES 308 308 Phosphoserine.
MOD_RES 333 333 Phosphothreonine.
MOD_RES 336 336 Phosphoserine. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 590 AA |
Protein Sequence | MDLMNGQASS VTIAATVSEK SSSSESLSEK GSELKKSFDA VVFDVLKVTP EEYAGQITLM 60
DVPVFKAIQP DELSSCGWNK KEKYSSAPNA VAFTRRFNHV SFWVVREILH AQTLKIRAEV 120
LSHYIKTAKK LYELNNLHAL MAVVSGLQSA PIFRLTKTWA LLSRKDKTTF EKLEYVMSKE 180
DNYKRLRDYI SSLKMTPCIP YLGIYLSDLT YIDSAYPSTG SILENEQRSN LMNNILRIIS 240
DLQQSCEYDI PILPHVQKYL NSVQYIEELQ KFVEDDNYKL SLKIEPGAST PRSAASREDL 300
AGPDIGASPQ GGRKSSAAAA AAAAAEGALL PQTPPSPRNL IPHGHRKCHS LGYNFIHKMN 360
TAEFKSATFP NAGPRHLLDD SVMEPHAPSR GQAESSTLSS GISIGSSDGS ELSEETSWPA 420
FERNRLYHSL GPVTRVPRNG YRSHTKASSS AESEDLAVHL YPGAVTIQGV LRRKTLLKEG 480
KKPTVASWTK YWAALCGTQL FYYAAKSLKA TERKHFKSTS NKNVSVVGWM VMMADDPEHP 540
DLFLLTDSEK GNSYKFQAGS RMNAMLWFKH LSAACQSNKQ QVPTNLMTFE 590 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |