CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011334
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-box protein YLR224W 
Protein Synonyms/Alias
  
Gene Name
 YLR224W 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
145SNFNSRPKERTLMQSubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). 
Sequence Annotation
 DOMAIN 8 45 F-box.  
Keyword
 Complete proteome; Reference proteome; Ubl conjugation; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 369 AA 
Protein Sequence
MNQSDSSLMD LPLEIHLSLL EYVPNELRAV NKYFYVLHNH SYKEKSLAWI AEDNYIWAVV 60
KHSLCLYVKS LDPLRQHARE IIQETKEPGF NVPLCMTKYI ADSWYIVYNA LQYPGKIINM 120
GWDKYTKSQD SNGSDSTSNF NSRPKERTLM QSLTALPVNF WSRRKDEPTP VNVWFYVKNA 180
HVARYIPKII TEIGICNYGP KQIVASAGYI NELITSEGIY CVNLGHLPRL YDEQIFEGTG 240
TTHLPLELKA IDRTDSDVCI NGDLVLLGYD FIPYQISKPW LLFRIEPVNS IEAIFNYSEC 300
SFSYQFAWSL ACLQSEEKIS FPRDTIIGHG LPYKPSKLIR IFVYKHPEQK QDLGQEIALP 360
NWNTPYLRR 369 
Gene Ontology
 GO:0019005; C:SCF ubiquitin ligase complex; IDA:SGD.
 GO:0030674; F:protein binding, bridging; ISA:SGD.
 GO:0071406; P:cellular response to methylmercury; IMP:SGD.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
 GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ISA:SGD. 
Interpro
  
Pfam
  
SMART
  
PROSITE
 PS50181; FBOX 
PRINTS