UniProt Accession

 GLRB_HUMAN; P48167; A8K3K2; D3DP23; F5GWE1 

Genbank Protein ID

 U33267; AF094754; AF094755; CD013911; AK290617; AC079403; CH471056; CH471056; BC032635 

Genbank Nucleotide ID

 AAB37750.1; AAC71033.1; AAC71034.1; BAF83306.1; EAX04872.1; EAX04873.1; AAH32635.1 

Protein Name

 Glycine receptor subunit beta 

Protein Synonyms/Alias

 Glycine receptor 58 kDa subunit 

Gene Name

 GLRB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
117	KWNDPRLKLPSDFRG	ubiquitination	[1]
136	TVDPTMYKCLWKPDL	ubiquitination	[1]
140	TMYKCLWKPDLFFAN	ubiquitination	[1]
198	PMDTQRCKMQLESFG	ubiquitination	[1]
369	AEKARIAKAEQADGK	ubiquitination	[1]
440	SNYDCYGKPIEVNNG	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). 

Sequence Annotation

 CARBOHYD 54 54 N-linked (GlcNAc...) (Potential).
 CARBOHYD 242 242 N-linked (GlcNAc...) (Potential).
 DISULFID 183 197 By similarity.  

Keyword

 Alternative splicing; Cell junction; Cell membrane; Chloride; Chloride channel; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 497 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0016934; F:extracellular-glycine-gated chloride channel activity; TAS:Reactome.
 GO:0007340; P:acrosome reaction; IEA:Compara.
 GO:0007628; P:adult walking behavior; IEA:Compara.
 GO:0007399; P:nervous system development; IMP:UniProtKB.
 GO:0007218; P:neuropeptide signaling pathway; IDA:UniProtKB.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0042391; P:regulation of membrane potential; IEA:Compara.
 GO:0060013; P:righting reflex; IEA:Compara.
 GO:0001964; P:startle response; IMP:UniProtKB.
 GO:0007268; P:synaptic transmission; IMP:UniProtKB.
 GO:0060012; P:synaptic transmission, glycinergic; IEA:Compara.
 GO:0007601; P:visual perception; IEA:Compara. 

Interpro

 IPR008060; Glycine_rcpt_B.
 IPR006202; Neur_chan_lig-bd.
 IPR006201; Neur_channel.
 IPR006029; Neurotrans-gated_channel_TM.
 IPR018000; Neurotransmitter_ion_chnl_CS. 

Pfam

 PF02931; Neur_chan_LBD
 PF02932; Neur_chan_memb 

SMART

  

PROSITE

 PS00236; NEUROTR_ION_CHANNEL 

PRINTS

 PR01677; GLYRBETA.
 PR00252; NRIONCHANNEL.