CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037325
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Anaphase-promoting complex subunit 4 
Protein Synonyms/Alias
  
Gene Name
 ANAPC4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
89FALADTKKIVLCDVEubiquitination[1]
147PKLPTLPKNYSNTSKubiquitination[1]
154KNYSNTSKIFSEENSubiquitination[2]
332LTVKGLKKLGQSIESubiquitination[2]
469DLYNRKGKYFNVERVubiquitination[1, 3]
521LFPYYPRKSLHFVKRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 809 AA 
Protein Sequence
MLRFPTCFPS FRVVGEKQLP QEIIFLVWSP KRDLIALANT AGEVLLHRLA SFHRVWSFPP 60
NENTGKEVTC LAWRPDGKLL AFALADTKKI VLCDVEKPES LHSFSVEAPV SCMHWMEVTV 120
ESSVLTSFYN AEDESNLLLP KLPTLPKNYS NTSKIFSEEN SDEIIKLLGD VRLNILVLGG 180
SSGFIELYAY GMFKIARVTG IAGTCLALCL SSDLKSLSVV TEVSTNGASE VSYFQLETNL 240
LYSFLPEVTR MARKFTHISA LLQYINLSLT CMCEAWEEIL MQMDSRLTKF VQEKNTTTSV 300
QDEFMHLLLW GKASAELQTL LMNQLTVKGL KKLGQSIESS YSSIQKLVIS HLQSGSESLL 360
YHLSELKGMA SWKQKYEPLG LDAAGIEEAI TAVGSFILKA NELLQVIDSS MKNFKAFFRW 420
LYVAMLRMTE DHVLPELNKV MTQKDITFVA EFLTEHFNEA PDLYNRKGKY FNVERVGQYL 480
KDEDDDLVSP PNTEGNQWYD FLQNSSHLKE SPLLFPYYPR KSLHFVKRRM ENIIDQCLQK 540
PADVIGKSMN QAICIPLYRD TRSEDSTRRL FKFPFLWNNK TSNLHYLLFT ILEDSLYKMC 600
ILRRHTDISQ SVSNGLIAIK FGSFTYATTE KVRRSIYSCL DAQFYDDETV TVVLKDTVGR 660
EGRDRLLVQL PLSLVYNSED SAEYQFTGTY STRLDEQCSA IPTRTMHFEK HWRLLESMKA 720
QYVAGNGFRK VSCVLSSNLR HVRVFEMDID DEWELDESSD EEEEASNKPV KIKEEVLSES 780
EAENQQAGAA ALAPEIVIKV EKLDPELDS 809 
Gene Ontology
 GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
 GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
 GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IEA:InterPro. 
Interpro
 IPR024789; APC4.
 IPR024790; APC4_long_dom.
 IPR017169; APC4_metazoa.
 IPR024977; Apc4_WD40_dom.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF12896; Apc4
 PF12894; Apc4_WD40 
SMART
  
PROSITE
  
PRINTS