CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031987
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribosomal protein S6 kinase alpha-2 
Protein Synonyms/Alias
 Ribosomal protein S6 kinase, 90kDa, polypeptide 2, isoform CRA_a; cDNA FLJ55331, highly similar to Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) 
Gene Name
 RPS6KA2 
Gene Synonyms/Alias
 hCG_2029617 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
361VKIIDKSKRDPSEEIubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Ribonucleoprotein; Ribosomal protein; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 644 AA 
Protein Sequence
MKVLKKATLK VRDRVRSKME RDILAEVNHP FIVKLHYAFQ TEGKLYLILD FLRGGDLFTR 60
LSKEVMFTEE DVKFYLAELA LALDHLHSLG IIYRDLKPEN ILLDEEGHIK ITDFGLSKEA 120
IDHDKRAYSF CGTIEYMAPE VVNRRGHTQS ADWWSFGVLM FEMLTGSLPF QGKDRKETMA 180
LILKAKLGMP QFLSGEAQSL LRALFKRNPC NRLGAGIDGV EEIKRHPFFV TIDWNTLYRK 240
EIKPPFKPAV GRPEDTFHFD PEFTARTPTD SPGVPPSANA HHLFRGFSFV ASSLIQEPSQ 300
QDLHKVPVHP IVQQLHGNNI HFTDGYEIKE DIGVGSYSVC KRCVHKATDT EYAVKIIDKS 360
KRDPSEEIEI LLRYGQHPNI ITLKDVYDDG KFVYLVMELM RGGELLDRIL RQRYFSEREA 420
SDVLCTITKT MDYLHSQGVV HRDLKPSNIL YRDESGSPES IRVCDFGFAK QLRAGNGLLM 480
TPCYTANFVA PEVLKRQGYD AACDIWSLGI LLYTMLAGFT PFANGPDDTP EEILARIGSG 540
KYALSGGNWD SISDAAKDVV SKMLHVDPHQ RLTAMQVLKH PWVVNREYLS PNQLSRQDVH 600
LVKGAMAATY FALNRTPQAP RLEPVLSSNL AQRRGMKRLT STRL 644 
Gene Ontology
 GO:0005840; C:ribosome; IEA:UniProtKB-KW.
 GO:0005819; C:spindle; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004711; F:ribosomal protein S6 kinase activity; IEA:Compara.
 GO:0002035; P:brain renin-angiotensin system; IEA:Compara.
 GO:0010659; P:cardiac muscle cell apoptotic process; IEA:Compara.
 GO:0071322; P:cellular response to carbohydrate stimulus; IEA:Compara.
 GO:0060047; P:heart contraction; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0001556; P:oocyte maturation; IEA:Compara.
 GO:0018105; P:peptidyl-serine phosphorylation; IEA:Compara.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0070613; P:regulation of protein processing; IEA:Compara. 
Interpro
 IPR000961; AGC-kinase_C.
 IPR011009; Kinase-like_dom.
 IPR017892; Pkinase_C.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase
 PF00433; Pkinase_C 
SMART
 SM00133; S_TK_X
 SM00220; S_TKc 
PROSITE
 PS51285; AGC_KINASE_CTER
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS