UniProt Accession

 RUVB1_MOUSE; P60122; O35753 

Genbank Protein ID

 AF100694; BC004718 

Genbank Nucleotide ID

 AAD02877.1; AAH04718.1 

Protein Name

 RuvB-like 1 

Protein Synonyms/Alias

 49 kDa TATA box-binding protein-interacting protein; 49 kDa TBP-interacting protein; DNA helicase p50; Pontin 52; TIP49a 

Gene Name

 Ruvbl1 

Gene Synonyms/Alias

 Tip49; Tip49a 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
171	AKGTKQLKLDPSIFE	ubiquitination	[1]
281	KLRGEINKVVNKYID	ubiquitination	[1]
453	ILADQQDKYMK****	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (By similarity). 

Sequence Annotation

 NP_BIND 70 77 ATP.
 MOD_RES 453 453 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Activator; ATP-binding; Cell cycle; Cell division; Chromatin regulator; Complete proteome; Direct protein sequencing; DNA damage; DNA recombination; DNA repair; Growth regulation; Helicase; Hydrolase; Mitosis; Nucleotide-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 456 AA 

Protein Sequence

Gene Ontology

 GO:0031011; C:Ino80 complex; IEA:InterPro.
 GO:0071339; C:MLL1 complex; ISS:UniProtKB.
 GO:0035267; C:NuA4 histone acetyltransferase complex; ISS:UniProtKB.
 GO:0030529; C:ribonucleoprotein complex; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0043141; F:ATP-dependent 5'-3' DNA helicase activity; IEA:InterPro.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0032508; P:DNA duplex unwinding; IEA:GOC.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0043968; P:histone H2A acetylation; ISS:UniProtKB.
 GO:0043967; P:histone H4 acetylation; ISS:UniProtKB.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR012340; NA-bd_OB-fold.
 IPR027417; P-loop_NTPase.
 IPR027238; RuvB-like.
 IPR010339; TIP49_C. 

Pfam

 PF06068; TIP49 

SMART

 SM00382; AAA 

PROSITE

  

PRINTS