CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008225
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription initiation factor TFIID subunit 6 
Protein Synonyms/Alias
 RNA polymerase II TBP-associated factor subunit E; Transcription initiation factor TFIID 70 kDa subunit; TAF(II)70; TAFII-70; TAFII70; Transcription initiation factor TFIID 80 kDa subunit; TAF(II)80; TAFII-80; TAFII80 
Gene Name
 TAF6 
Gene Synonyms/Alias
 TAF2E; TAFII70 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
85DEVSYRIKEIAQDALubiquitination[1]
113SDIDYALKLKNVEPLubiquitination[1]
115IDYALKLKNVEPLYGubiquitination[1]
275CVGSCEAKRAEALQSubiquitination[1]
398RITKTFTKSWVDEKTubiquitination[1]
466HVQSLLLKHCAPVLAubiquitination[1]
502LLCSQVVKARAQAALubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. 
Sequence Annotation
 MOD_RES 248 248 Phosphothreonine (By similarity).
 MOD_RES 253 253 Phosphotyrosine (By similarity).
 MOD_RES 264 264 Phosphoserine (By similarity).
 MOD_RES 653 653 Phosphoserine.
 MOD_RES 660 660 Phosphothreonine.  
Keyword
 Alternative splicing; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 677 AA 
Protein Sequence
MTKRRLQTIT ACLQLREGSP SLHRGLHPSR EEKRDSRMAE EKKLKLSNTV LPSESMKVVA 60
ESMGIAQIQE ETCQLLTDEV SYRIKEIAQD ALKFMHMGKR QKLTTSDIDY ALKLKNVEPL 120
YGFHAQEFIP FRFASGGGRE LYFYEEKEVD LSDIINTPLP RVPLDVCLKA HWLSIEGCQP 180
AIPENPPPAP KEQQKAEATE PLKSAKPGQE EDGPLKGKGQ GATTADGKGK EKKAPPLLEG 240
APLRLKPRSI HELSVEQQLY YKEITEACVG SCEAKRAEAL QSIATDPGLY QMLPRFSTFI 300
SEGVRVNVVQ NNLALLIYLM RMVKALMDNP TLYLEKYVHE LIPAVMTCIV SRQLCLRPDV 360
DNHWALRDFA ARLVAQICKH FSTTTNNIQS RITKTFTKSW VDEKTPWTTR YGSIAGLAEL 420
GHDVIKTLIL PRLQQEGERI RSVLDGPVLS NIDRIGADHV QSLLLKHCAP VLAKLRPPPD 480
NQDAYRAEFG SLGPLLCSQV VKARAQAALQ AQQVNRTTLT ITQPRPTLTL SQAPQPGPRT 540
PGLLKVPGSI ALPVQTLVSA RAAAPPQPSP PPTKFIVMSS SSSAPSTQQV LSLSTSAPGS 600
GSTTTSPVTT TVPSVQPIVK LVSTATTAPP STAPSGPGSV QKYIVVSLPP TGEGKGGPTS 660
HPSPVPPPAS SPSPLSGSAL CGGKQEAGDS PPPAPGTPKA NGSQPNSGSP QPAP 714 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0071339; C:MLL1 complex; IDA:UniProtKB.
 GO:0005669; C:transcription factor TFIID complex; IDA:MGI.
 GO:0033276; C:transcription factor TFTC complex; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IDA:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0045786; P:negative regulation of cell cycle; IDA:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB.
 GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; TAS:Reactome.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0022415; P:viral reproductive process; TAS:Reactome. 
Interpro
 IPR011989; ARM-like.
 IPR011442; DUF1546.
 IPR009072; Histone-fold.
 IPR004823; TAF_TATA-bd. 
Pfam
 PF07571; DUF1546
 PF02969; TAF 
SMART
 SM00803; TAF 
PROSITE
  
PRINTS