UniProt Accession

 PANE_YEAST; P38787; D3DL12 

Genbank Protein ID

 U00061; BK006934 

Genbank Nucleotide ID

 AAB68390.1; DAA06756.1 

Protein Name

 2-dehydropantoate 2-reductase 

Protein Synonyms/Alias

 Ketopantoate reductase; KPA reductase; KPR 

Gene Name

 PAN5 

Gene Synonyms/Alias

 YHR063C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
48	ERLAQFQKTNGNNIS	ubiquitination	[1]
83	CPETFSKKPIDNLVV	acetylation	[2]
196	AANNSLVKLLTEPKF	acetylation	[2]
202	VKLLTEPKFAKEFGI	acetylation	[2]
351	NLDPNCCKVNKTIGE	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity). 

Sequence Annotation

 NP_BIND 13 18 NADP (By similarity).
 ACT_SITE 224 224 Proton donor (By similarity).
 BINDING 119 119 NADP; via amide nitrogen (By similarity).
 BINDING 119 119 Substrate (By similarity).
 BINDING 228 228 Substrate (By similarity).
 BINDING 232 232 Substrate (By similarity).
 BINDING 316 316 Substrate (By similarity).
 BINDING 328 328 NADP (By similarity).  

Keyword

 Complete proteome; NADP; Oxidoreductase; Pantothenate biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 379 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0008677; F:2-dehydropantoate 2-reductase activity; ISS:SGD.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0015940; P:pantothenate biosynthetic process; ISS:SGD. 

Interpro

 IPR008927; 6-PGluconate_DH_C-like.
 IPR003710; ApbA.
 IPR013752; ApbA_C.
 IPR013332; ApbA_N.
 IPR013328; DH_multihelical.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF02558; ApbA
 PF08546; ApbA_C 

SMART

  

PROSITE

  

PRINTS