UniProt Accession

 DHRS3_HUMAN; O75911; B2R7F3; Q5VUY3; Q6UY38; Q9BUC8 

Genbank Protein ID

 AF061741; AF179237; AF179234; AF179235; AF179236; AY358093; AK312961; BX648476; AL513016; AL645761; AL645761; AL513016; CH471130; BC002730 

Genbank Nucleotide ID

 AAC63263.1; AAD55402.1; AAD55402.1; AAD55402.1; AAD55402.1; AAQ88460.1; BAG35800.1; CAI46033.1; CAH74172.1; CAH74172.1; CAI14999.1; CAI14999.1; EAW71743.1; AAH02730.1 

Protein Name

 Short-chain dehydrogenase/reductase 3 

Protein Synonyms/Alias

 DD83.1; Retinal short-chain dehydrogenase/reductase 1; retSDR1 

Gene Name

 DHRS3 

Gene Synonyms/Alias

 UNQ2424/PRO4983 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
32	VGLVLPAKLRDLSRE	ubiquitination	[1]
130	NAAVVHGKSLMDSDD	ubiquitination	[2]
142	SDDDALLKSQHINTL	ubiquitination	[2, 3, 4]
156	LGQFWTTKAFLPRML	ubiquitination	[1, 3, 4]
242	PNLFPPLKPETVARR	ubiquitination	[2, 4]
299	YTCMNTFKGRT****	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH. 

Sequence Annotation

 ACT_SITE 188 188 Proton acceptor (By similarity).
 BINDING 175 175 Substrate (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Membrane; NADP; Oxidoreductase; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 302 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042622; C:photoreceptor outer segment membrane; TAS:Reactome.
 GO:0009055; F:electron carrier activity; TAS:UniProtKB.
 GO:0052650; F:NADP-retinol dehydrogenase activity; IEA:EC.
 GO:0000166; F:nucleotide binding; TAS:ProtInc.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0042572; P:retinol metabolic process; TAS:UniProtKB.
 GO:0007601; P:visual perception; TAS:ProtInc. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.