CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002275
UniProt Accession
Genbank Protein ID
 J02999 
Genbank Nucleotide ID
Protein Name
 Ras-related protein Rab-2A 
Protein Synonyms/Alias
  
Gene Name
 Rab2a 
Gene Synonyms/Alias
 Rab2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
8MAYAYLFKYIIIGDTmethylation[1]
Reference
 [1] A method for the comprehensive proteomic analysis of membrane proteins.
 Wu CC, MacCoss MJ, Howell KE, Yates JR 3rd.
 Nat Biotechnol. 2003 May;21(5):532-8. [PMID: 12692561] 
Functional Description
 Required for protein transport from the endoplasmic reticulum to the Golgi complex (By similarity). 
Sequence Annotation
 NP_BIND 13 21 GTP (By similarity).
 NP_BIND 61 65 GTP (By similarity).
 NP_BIND 119 122 GTP (By similarity).
 NP_BIND 149 151 GTP (By similarity).
 REGION 2 19 Required for interaction with PRKCI (By
 MOTIF 35 43 Effector region (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 LIPID 211 211 S-geranylgeranyl cysteine (By
 LIPID 212 212 S-geranylgeranyl cysteine (By  
Keyword
 Acetylation; Complete proteome; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 212 AA 
Protein Sequence
MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTMG VEFGARMITI DGKQIKLQIW 60
DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW LEDARQHSNS NMVIMLIGNK 120
SDLESRREVK KEEGEAFARE HGLIFMETSA KTASNVEEAF INTAKEIYEK IQEGVFDINN 180
EANGIKIGPQ HAATNASHGG NQGGQQAGGG CC 212 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IDA:RGD.
 GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IDA:RGD.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0019003; F:GDP binding; ISS:UniProtKB.
 GO:0005525; F:GTP binding; ISS:UniProtKB.
 GO:0003924; F:GTPase activity; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0032482; P:Rab protein signal transduction; IC:RGD.
 GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 
Pfam
 PF00071; Ras 
SMART
 SM00175; RAB 
PROSITE
 PS51419; RAB 
PRINTS
 PR00449; RASTRNSFRMNG.