CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021005
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative L-aspartate dehydrogenase 
Protein Synonyms/Alias
 Aspartate dehydrogenase domain-containing protein 
Gene Name
 Aspdh 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
12TLPQVPYKVGVVGYGubiquitination[1]
119QQLLEASKRWGHTVFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity). 
Sequence Annotation
 BINDING 131 131 NAD; via amide nitrogen (By similarity).
 BINDING 196 196 NAD (By similarity).  
Keyword
 Complete proteome; Direct protein sequencing; NAD; NADP; Oxidoreductase; Pyridine nucleotide biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 287 AA 
Protein Sequence
MATSTLPQVP YKVGVVGYGR LGQSLVSRLL AQGSELGLEL VFVWNRDPGR MAGSVPPALQ 60
LQDLTALEER HPDLVVEVAH PKIIHESGAQ ILRHANLLVG SPSALADQTT EQQLLEASKR 120
WGHTVFVARG ALWGSEDISR LDAAGGLQSL RVTMATHPDG FRLEGPLAAA HSSGPRTVLY 180
EGPVRGLCPL APRNSNTMAA AALAAPSLGF DRVIGVLVAD LSLTDMHVVD VELLGPPGPS 240
GRSFAVHTHR ENPAQPGAVT GSATVTAFWH SLLGCCQLTS RPGIHLC 287 
Gene Ontology
 GO:0033735; F:aspartate dehydrogenase activity; IEA:EC.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006742; P:NADP catabolic process; IEA:InterPro. 
Interpro
 IPR005106; Asp/hSer_DH_NAD-bd.
 IPR002811; Asp_DH.
 IPR011182; Asp_DH_NAD_syn.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF01958; DUF108
 PF03447; NAD_binding_3 
SMART
  
PROSITE
  
PRINTS