| Tag | Content |
|---|
| CPLM ID | CPLM-022110 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CREB/ATF bZIP transcription factor |
Protein Synonyms/Alias | Host cell factor-binding transcription factor Zhangfei; HCF-binding transcription factor Zhangfei |
Gene Name | CREBZF |
Gene Synonyms/Alias | ZF |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 312 | DYALPVGKQKQDLLE | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1- dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. |
Sequence Annotation | DOMAIN 204 267 bZIP.
REGION 219 226 Basic motif (By similarity).
REGION 232 267 Leucine-zipper (By similarity).
MOTIF 303 306 HCFC1-binding motif (HBM). |
Keyword | Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 354 AA |
Protein Sequence | MRHSLTKLLA ASGSNSPTRS ESPEPAATCS LPSDLTRAAA GEEETAAAGS PGRKQQFGDE 60
GELEAGRGSR GGVAVRAPSP EEMEEEAIAS LPGEETEDMD FLSGLELADL LDPRQPDWHL 120
DPGLSSPGPL SSSGGGSDSG GLWRGDDDDE AAAAEMQRFS DLLQRLLNGI GGCSSSSDSG 180
SAEKRRRKSP GGGGGGGSGN DNNQAATKSP RKAAAAAARL NRLKKKEYVM GLESRVRGLA 240
AENQELRAEN RELGKRVQAL QEESRYLRAV LANETGLARL LSRLSGVGLR LTTSLFRDSP 300
AGDHDYALPV GKQKQDLLEE DDSAGGVCLH VDKDKVSVEF CSACARKASS SLKM 354 |
Gene Ontology | GO:0005634; C:nucleus; IDA:UniProtKB. GO:0003677; F:DNA binding; NAS:UniProtKB. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0045814; P:negative regulation of gene expression, epigenetic; IEP:UniProtKB. GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB. GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IDA:UniProtKB. GO:0009615; P:response to virus; IDA:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IDA:UniProtKB. |
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PRINTS | |