UniProt Accession

 MOB1_YEAST; P40484; D6VVI1 

Genbank Protein ID

 Z38125; BK006942 

Genbank Nucleotide ID

 CAA86274.1; DAA08447.1 

Protein Name

 DBF2 kinase activator protein MOB1 

Protein Synonyms/Alias

 MPS1 binder 1; Maintenance of ploidy protein MOB1 

Gene Name

 MOB1 

Gene Synonyms/Alias

 YIL106W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
22	IRSTRGFKWNTANAA	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Functions as an activator subunit for the DBF2 protein kinase. Binds to DBF2, which is required for the phosphorylation and activation of DBF2 by the upstream kinase CDC15 in late anaphase. DBF2-MOB1 is part of the mitotic exit network (MEN) signaling cascade, which regulates release from the nucleus and activity of phosphatase CDC14. Required for inactivation of mitotic cyclin-dependent kinase for exit from mitosis, cytokinesis and G1 gene transcription. 

Sequence Annotation

 METAL 179 179 Zinc.
 METAL 184 184 Zinc.
 METAL 261 261 Zinc.
 METAL 266 266 Zinc.
 MOD_RES 34 34 Phosphoserine.
 MOD_RES 36 36 Phosphoserine.
 MOD_RES 80 80 Phosphoserine.
 MOD_RES 229 229 Phosphoserine.  

Keyword

 3D-structure; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Metal-binding; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 314 AA 

Protein Sequence

Gene Ontology

 GO:0005935; C:cellular bud neck; IDA:SGD.
 GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0034399; C:nuclear periphery; IDA:SGD.
 GO:0005816; C:spindle pole body; IDA:SGD.
 GO:0019207; F:kinase regulator activity; IDA:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006468; P:protein phosphorylation; IDA:SGD.
 GO:0007096; P:regulation of exit from mitosis; TAS:SGD. 

Interpro

 IPR005301; Mob1_phocein. 

Pfam

 PF03637; Mob1_phocein 

SMART

  

PROSITE

  

PRINTS