UniProt Accession

 MARCS_MOUSE; P26645 

Genbank Protein ID

 M60474; BC046601 

Genbank Nucleotide ID

 AAA39491.1; AAH46601.1 

Protein Name

 Myristoylated alanine-rich C-kinase substrate 

Protein Synonyms/Alias

 MARCKS 

Gene Name

 Marcks 

Gene Synonyms/Alias

 Macs 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
11	QFSKTAAKGEATAER	ubiquitination	[1]
158	FSFKKSFKLSGFSFK	acetylation	[2]
158	FSFKKSFKLSGFSFK	ubiquitination	[1]
165	KLSGFSFKKSKKESG	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. 

Sequence Annotation

 REGION 145 169 Calmodulin-binding (PSD).
 MOD_RES 27 27 Phosphoserine (By similarity).
 MOD_RES 46 46 Phosphoserine.
 MOD_RES 63 63 Phosphoserine (By similarity).
 MOD_RES 113 113 Phosphoserine; by MAPK.
 MOD_RES 128 128 Phosphoserine.
 MOD_RES 138 138 Phosphoserine.
 MOD_RES 140 140 Phosphoserine.
 MOD_RES 143 143 Phosphothreonine.
 MOD_RES 152 152 Phosphoserine; by PKC.
 MOD_RES 156 156 Phosphoserine; by PKC.
 MOD_RES 160 160 Phosphoserine (By similarity).
 MOD_RES 163 163 Phosphoserine; by PKC.
 MOD_RES 171 171 Phosphoserine.
 MOD_RES 246 246 Phosphoserine.
 LIPID 2 2 N-myristoyl glycine (By similarity).  

Keyword

 3D-structure; Actin-binding; Calmodulin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Lipoprotein; Membrane; Myristate; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 309 AA 

Protein Sequence

Gene Ontology

 GO:0005938; C:cell cortex; IDA:MGI.
 GO:0005813; C:centrosome; IDA:MGI.
 GO:0042585; C:germinal vesicle; IDA:MGI.
 GO:0016020; C:membrane; IDA:MGI. 

Interpro

 IPR002101; MARCKS. 

Pfam

 PF02063; MARCKS 

SMART

  

PROSITE

 PS00826; MARCKS_1
 PS00827; MARCKS_2 

PRINTS

 PR00963; MARCKS.