CPLM-001120

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-001120

UniProt Accession

DEPD5_HUMAN; O75140; A6H8V6; A8MPX9; B4DH93; B9EGN9; Q5K3V5; Q5THY9; Q5THZ0; Q5THZ1; Q5THZ3; Q68DR1; Q6MZX3; Q6PEZ1; Q9UGV8; Q9UH13

Genbank Protein ID

AJ698950; AJ698951; AJ704764; AB014545; AK294987; AC005004; AL022331; Z82190; Z83856; AL022331; AC005004; AL022331; AC005004; Z82190; Z83856; AL022331; AC005004; Z82190; Z83856; AL022331; AC005004; Z82190; Z83856; Z83856; AL022331; Z82190; Z83856; AC005004; AL022331; Z82190; Z83856; AC005004; AL022331; Z82190; Z83856; AC005004; AL022331; Z82190; Z82190; AL022331; Z83856; Z82190; AC005004; AL022331; Z83856; Z82190; AC005004; AL022331; Z83856; Z82190; CH471095; BC057797; BC136612; BC146766; BX640828; CR749304

Genbank Nucleotide ID

CAG27889.1; CAG27890.1; CAG28924.1; BAA31620.2; BAG58054.1; AAD08635.1; CAI17972.1; CAI17972.1; CAI17972.1; CAI17973.1; CAI17973.1; CAI17974.1; CAI17974.1; CAI17974.1; CAI17974.1; CAI17975.1; CAI17975.1; CAI17975.1; CAI17975.1; CAI17976.1; CAI17976.1; CAI17976.1; CAI17976.1; CAI18776.1; CAI18776.1; CAI18776.1; CAI18777.1; CAI18777.1; CAI18777.1; CAI18777.1; CAI18778.1; CAI18778.1; CAI18778.1; CAI18778.1; CAI18779.1; CAI18779.1; CAI18779.1; CAI18779.1; CAI19696.1; CAI19696.1; CAI19696.1; CAI19697.1; CAI19697.1; CAI19697.1; CAI19697.1; CAI19698.1; CAI19698.1; CAI19698.1; CAI19698.1; CAI19699.1; EAW59996.1; AAH57797.1; AAI36613.1; AAI46767.1; CAE45904.1; CAH18159.1

Protein Name

DEP domain-containing protein 5

Protein Synonyms/Alias

Gene Name

DEPDC5

Gene Synonyms/Alias

KIAA0645

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
1574	KFADRLLKDFTDFCI	ubiquitination	[1, 2]

Reference

[1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]

Functional Description

Sequence Annotation

DOMAIN 1187 1262 DEP.

Keyword

Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; Epilepsy; Polymorphism; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1603 AA

Protein Sequence

MRTTKVYKLV IHKKGFGGSD DELVVNPKVF PHIKLGDIVE IAHPNDEYSP LLLQVKSLKE 60
DLQKETISVD QTVTQVFRLR PYQDVYVNVV DPKDVTLDLV ELTFKDQYIG RGDMWRLKKS 120
LVSTCAYITQ KVEFAGIRAQ AGELWVKNEK VMCGYISEDT RVVFRSTSAM VYIFIQMSCE 180
MWDFDIYGDL YFEKAVNGFL ADLFTKWKEK NCSHEVTVVL FSRTFYDAKS VDEFPEINRA 240
SIRQDHKGRF YEDFYKVVVQ NERREEWTSL LVTIKKLFIQ YPVLVRLEQA EGFPQGDNST 300
SAQGNYLEAI NLSFNVFDKH YINRNFDRTG QMSVVITPGV GVFEVDRLLM ILTKQRMIDN 360
GIGVDLVCMG EQPLHAVPLF KLHNRSAPRD SRLGDDYNIP HWINHSFYTS KSQLFCNSFT 420
PRIKLAGKKP ASEKAKNGRD TSLGSPKESE NALPIQVDYD AYDAQVFRLP GPSRAQCLTT 480
CRSVRERESH SRKSASSCDV SSSPSLPSRT LPTEEVRSQA SDDSSLGKSA NILMIPHPHL 540
HQYEVSSSLG YTSTRDVLEN MMEPPQRDSS APGRFHVGSA ESMLHVRPGG YTPQRALINP 600
FAPSRMPMKL TSNRRRWMHT FPVGPSGEAI QIHHQTRQNM AELQGSGQRD PTHSSAELLE 660
LAYHEAAGRH SNSRQPGDGM SFLNFSGTEE LSVGLLSNSG AGMNPRTQNK DSLEDSVSTS 720
PDPILTLSAP PVVPGFCCTV GVDWKSLTTP ACLPLTTDYF PDRQGLQNDY TEGCYDLLPE 780
ADIDRRDEDG VQMTAQQVFE EFICQRLMQG YQIIVQPKTQ KPNPAVPPPL SSSPLYSRGL 840
VSRNRPEEED QYWLSMGRTF HKVTLKDKMI TVTRYLPKYP YESAQIHYTY SLCPSHSDSE 900
FVSCWVEFSH ERLEEYKWNY LDQYICSAGS EDFSLIESLK FWRTRFLLLP ACVTATKRIT 960
EGEAHCDIYG DRPRADEDEW QLLDGFVRFV EGLNRIRRRH RSDRMMRKGT AMKGLQMTGP 1020
ISTHSLESTA PPVGKKGTSA LSALLEMEAS QKCLGEQQAA VHGGKSSAQS AESSSVAMTP 1080
TYMDSPRKDG AFFMEFVRSP RTASSAFYPQ VSVDQTATPM LDGTSLGICT GQSMDRGNSQ 1140
TFGNSQNIGE QGYSSTNSSD SSSQQLVASS LTSSSTLTEI LEAMKHPSTG VQLLSEQKGL 1200
SPYCFISAEV VHWLVNHVEG IQTQAMAIDI MQKMLEEQLI THASGEAWRT FIYGFYFYKI 1260
VTDKEPDRVA MQQPATTWHT AGVDDFASFQ RKWFEVAFVA EELVHSEIPA FLLPWLPSRP 1320
ASYASRHSSF SRSFGGRSQA AALLAATVPE QRTVTLDVDV NNRTDRLEWC SCYYHGNFSL 1380
NAAFEIKLHW MAVTAAVLFE MVQGWHRKAT SCGFLLVPVL EGPFALPSYL YGDPLRAQLF 1440
IPLNISCLLK EGSEHLFDSF EPETYWDRMH LFQEAIAHRF GFVQDKYSAS AFNFPAENKP 1500
QYIHVTGTVF LQLPYSKRKF SGQQRRRRNS TSSTNQNMFC EERVGYNWAY NTMLTKTWRS 1560
SATGDEKFAD RLLKDFTDFC INRDNRLVTF WTSCLEKMHA SAP 1603

Gene Ontology

GO:0005829; C:cytosol; ISS:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.

Interpro

IPR000591; DEP_dom.
IPR027244; IML1.
IPR011991; WHTH_DNA-bd_dom.

Pfam

PF00610; DEP
PF12257; DUF3608

SMART

SM00049; DEP

PROSITE

PS50186; DEP

PRINTS