| Tag | Content |
|---|
| CPLM ID | CPLM-022938 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Metalloreductase STEAP1 |
Protein Synonyms/Alias | Six-transmembrane epithelial antigen of prostate 1 |
Gene Name | STEAP1 |
Gene Synonyms/Alias | PRSS24; STEAP |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 30 | EEDDYLHKDTGETSM | ubiquitination | [1] | | 329 | HGWEDVTKINKTEIC | ubiquitination | [1] | | 332 | EDVTKINKTEICSQL | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity). |
Sequence Annotation | DOMAIN 118 265 Ferric oxidoreductase.
METAL 175 175 Iron (heme axial ligand) (By similarity).
METAL 268 268 Iron (heme axial ligand) (By similarity). |
Keyword | Complete proteome; Copper; Electron transport; Endosome; FAD; Flavoprotein; Ion transport; Iron; Iron transport; Membrane; Metal-binding; NAD; Oxidoreductase; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 339 AA |
Protein Sequence | MESRKDITNQ EELWKMKPRR NLEEDDYLHK DTGETSMLKR PVLLHLHQTA HADEFDCPSE 60
LQHTQELFPQ WHLPIKIAAI IASLTFLYTL LREVIHPLAT SHQQYFYKIP ILVINKVLPM 120
VSITLLALVY LPGVIAAIVQ LHNGTKYKKF PHWLDKWMLT RKQFGLLSFF FAVLHAIYSL 180
SYPMRRSYRY KLLNWAYQQV QQNKEDAWIE HDVWRMEIYV SLGIVGLAIL ALLAVTSIPS 240
VSDSLTWREF HYIQSKLGIV SLLLGTIHAL IFAWNKWIDI KQFVWYTPPT FMIAVFLPIV 300
VLIFKSILFL PCLRKKILKI RHGWEDVTKI NKTEICSQL 339 |
Gene Ontology | GO:0005911; C:cell-cell junction; TAS:ProtInc. GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0015267; F:channel activity; TAS:ProtInc. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. GO:0006811; P:ion transport; IEA:UniProtKB-KW. GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW. |
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SMART | |
PROSITE | |
PRINTS | |