CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013145
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ras GTPase-activating-like protein IQGAP2 
Protein Synonyms/Alias
  
Gene Name
 Iqgap2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
80VYLAKLAKFFAPKMVubiquitination[1]
85LAKFFAPKMVSEKKIubiquitination[1]
127MEAIGLPKIFYPETTubiquitination[1]
231AIEKGVAKQTIITLRubiquitination[1]
257SLSQEYQKELWEAKKubiquitination[1]
552VNECLDRKQSDHILTubiquitination[1]
578ILPECANKYYDTLVKubiquitination[1]
585KYYDTLVKAKESKTDubiquitination[1]
756DHKNEIVKIQSLLRAubiquitination[1]
771SKARDDYKALVGSENubiquitination[1]
814LREEVVTKIRANQQLubiquitination[1]
823RANQQLEKDLNLMDIubiquitination[1]
837IKIGLLVKNRITLEDubiquitination[1]
855HRKKLNKKKGGEIEIubiquitination[1]
856RKKLNKKKGGEIEILubiquitination[1]
869ILNNTDNKGIKSLSKubiquitination[1]
880SLSKERRKTLETYQQubiquitination[1]
910IFQMPQNKSTKFMDTacetylation[2]
910IFQMPQNKSTKFMDTsuccinylation[2]
910IFQMPQNKSTKFMDTubiquitination[1]
940YLLLKLFKTALEEEIubiquitination[1]
950LEEEIKSKVDQVQDIubiquitination[1]
990QLLAPVVKEIIEDKAubiquitination[1]
996VKEIIEDKALVINTNubiquitination[1]
1024TQTGEASKLPYDVTTubiquitination[1]
1041ALTYPEVKNKLEASIubiquitination[1]
1043TYPEVKNKLEASIENubiquitination[1]
1177ETYQEFRKYFQEACDubiquitination[1]
1289LTSKYDVKDGEAVDGubiquitination[1]
1305SLMIKTKKLIIDVTRubiquitination[1]
1337QQELEHAKDMESRAVubiquitination[1]
1354SRTPEEGKQSQAVIEubiquitination[1]
1390QTGHVSSKNKYQDILubiquitination[1]
1392GHVSSKNKYQDILNEubiquitination[1]
1402DILNEIAKDIRNQRIubiquitination[1]
1420LRKAELSKLQQTLNAubiquitination[1]
1430QTLNALNKKAAFYEDubiquitination[1]
1431TLNALNKKAAFYEDQubiquitination[1]
1454KTCVDNLKRKNSRRSubiquitination[1]
1489TAAKLHDKGVLLGIDubiquitination[1]
1524GIFDVRSKFLGVEMEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. 
Sequence Annotation
 DOMAIN 41 156 CH.
 DOMAIN 594 627 WW.
 DOMAIN 690 719 IQ 1.
 DOMAIN 720 749 IQ 2.
 DOMAIN 750 779 IQ 3.
 DOMAIN 917 1150 Ras-GAP.
 MOD_RES 16 16 Phosphoserine.
 MOD_RES 1389 1389 Phosphoserine.  
Keyword
 Calmodulin-binding; Complete proteome; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1575 AA 
Protein Sequence
MPHEELPSLQ RPRYGSIVDD ERLSAEEMDE RRRQNIAYEY LCHLEEAKRW MEVCLVEELP 60
PTTELEEGLR NGVYLAKLAK FFAPKMVSEK KIYDVEQTRY KKSGLHFRHT DNTVQWLRAM 120
EAIGLPKIFY PETTDVYDRK NIPRMIYCIH ALSLYLFKLG IAPQIQDLLG KVDFTEEEIS 180
NMRKELEKYG IQMPAFSKIG GILANELSVD EAALHAAVIA INEAIEKGVA KQTIITLRNP 240
NAVLTCVDDS LSQEYQKELW EAKKKKEESA KLKNSCISEE ERDAYEELLT QAEIQSNIST 300
VNRMAAVDHI NAVLQEGDPE NTLLALKKPE AQLPAVYPFA AVMYQNELFN LQKQNTSNYL 360
AHEELLIAVE MLSAVALLNQ ALESSDLVAV QNQLRSPTIG FNNLDEAHVD RYADALLSVK 420
QEALSQGQDT LSWNEIQNCI DMINNQIQEE NDRMVVLGYI NEAIDAGNPL KTLDTLLLPT 480
ANIRDVDPDC AQHYQDVLFY TKSQKLGDPK NVSKVLWLDE IQQAINEANV DENRAKQWVT 540
LVVDVNECLD RKQSDHILTA LKSSPSNIHN ILPECANKYY DTLVKAKESK TDNESSEGSW 600
VTLNVQEKYN YYYNTDSKEG SWVPPELCLS KESWLTGEEI EDIVEEVTSD YIREKLWSAS 660
EDLLVRFEAT TLGPALREEF EARKAFLYEQ TESVVKIQAF WKGFKQRQEY LHRQQVFAGN 720
VDSVVKIQSW FRMVTARKSY LSRLRYFEDH KNEIVKIQSL LRASKARDDY KALVGSENPP 780
LTVIRKFVYL LDQSDLDFQE ELEVARLREE VVTKIRANQQ LEKDLNLMDI KIGLLVKNRI 840
TLEDVISHRK KLNKKKGGEI EILNNTDNKG IKSLSKERRK TLETYQQLFY LLQTKPSYLA 900
KLIFQMPQNK STKFMDTVIF TLYNYASNQR EEYLLLKLFK TALEEEIKSK VDQVQDIVTG 960
NPTVIKMVVS FNRGARGQNT LRQLLAPVVK EIIEDKALVI NTNPVEVYKA WVNQLETQTG 1020
EASKLPYDVT TEQALTYPEV KNKLEASIEN LRKVTDKVLG SIISSLDLLP YGLRYIAKVL 1080
KNSIREKFPD ATEEELLKIV GNLLYYRYMN PAIVAPDGFD IIDMTAGGQI NSNQRRNLGS 1140
VAKVLQHAAS NKLFEGENEH LSSMNNYLSE TYQEFRKYFQ EACDVPEPEE KFNMDKYTDL 1200
VTVSKPVIYI SIEEIINTHL LLLEHQDAIA TEKSDLLNEL LESLGEVPTV ESFLGEGAVD 1260
PNDPNKENTL NQLSKTEISL SLTSKYDVKD GEAVDGRSLM IKTKKLIIDV TRNQPGSTLT 1320
EILETPATGQ QELEHAKDME SRAVVDSRTP EEGKQSQAVI EDARLPLEQK KRKIQRNLRT 1380
LEQTGHVSSK NKYQDILNEI AKDIRNQRIH RKLRKAELSK LQQTLNALNK KAAFYEDQIN 1440
YYDTYIKTCV DNLKRKNSRR SIKLDGKAEP KGTKRVKPVR YTAAKLHDKG VLLGIDDLQT 1500
NQFKNVMFDI IATEDMGIFD VRSKFLGVEM EKVQLNIQDL LQMQYEGVAV MKMFDKVKVN 1560
VNLLIYLLNK KFYGK 1575 
Gene Ontology
 GO:0005874; C:microtubule; IEA:Compara.
 GO:0005902; C:microvillus; IDA:MGI.
 GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
 GO:0032320; P:positive regulation of Ras GTPase activity; IEA:GOC.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR001715; CH-domain.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027417; P-loop_NTPase.
 IPR001936; RasGAP.
 IPR000593; RasGAP_C.
 IPR023152; RasGAP_CS.
 IPR008936; Rho_GTPase_activation_prot.
 IPR001202; WW_dom. 
Pfam
 PF00307; CH
 PF00612; IQ
 PF00616; RasGAP
 PF03836; RasGAP_C 
SMART
 SM00033; CH
 SM00015; IQ
 SM00323; RasGAP 
PROSITE
 PS50021; CH
 PS50096; IQ
 PS00509; RAS_GTPASE_ACTIV_1
 PS50018; RAS_GTPASE_ACTIV_2
 PS01159; WW_DOMAIN_1
 PS50020; WW_DOMAIN_2 
PRINTS