CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030652
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RNA pseudouridylate synthase domain-containing protein 2 
Protein Synonyms/Alias
 cDNA FLJ57803, highly similar to Homo sapiens RNA pseudouridylate synthase domain containing 2 (RPUSD2), mRNA 
Gene Name
 RPUSD2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
243VRDRQLEKEYVCRVEacetylation[1]
243VRDRQLEKEYVCRVEubiquitination[2]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 484 AA 
Protein Sequence
MWLDRRGWLR VLGHWRYDLR RPSFTRTWSG DKGPMAETVS TQVGTEGGLR ASHQQNGDAG 60
GDAKVELSPG PPKPAGREVE PAPVGGEHPS AAAPGPGKHK KRRGATRERV VPPPKKRRTG 120
VSFGDEHFAE TSYYFEGGLR KDNDFLRNTV HRHEPPVTAE PIRLLAENED VVVVDKPSSI 180
PVHPCGRFRH NTVIFILGKE HQLKELHPLH RLDRLTSGVL MFAKTAAVSE RIHEQVRDRQ 240
LEKEYVCRVE GEFPTEEVTC KEPILVVSYK VGVCRVDPRG KPCETVFQRL SYNGQSSVVR 300
CRPLTGRTHQ IRVHLQFLGH PILNDPIYNS VAWGPSRGRG GYIPKTNEEL LRDLVAEHQA 360
KQSLDVLDLC EGDLSPGLTD STAPSSELGK DDLEELAAAA QKMEEVAEAA PQELDTIALA 420
SEKAVETDVM NQETDPLCAE CRLVRQDPLP QDLVMFLHAL RYKGPGFEYF SPMPAWAQDD 480
WQKD 484 
Gene Ontology
 GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0001522; P:pseudouridine synthesis; IEA:InterPro. 
Interpro
 IPR020103; PsdUridine_synth_cat_dom.
 IPR006225; PsdUridine_synth_RluC/D.
 IPR006224; PsdUridine_synth_RluC/D_CS.
 IPR006145; PsdUridine_synth_RsuA/RluD. 
Pfam
 PF00849; PseudoU_synth_2 
SMART
  
PROSITE
 PS01129; PSI_RLU 
PRINTS