CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000063
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acetyl-coenzyme A transporter 1 
Protein Synonyms/Alias
 AT-1; Acetyl-CoA transporter 1; Solute carrier family 33 member 1 
Gene Name
 SLC33A1 
Gene Synonyms/Alias
 ACATN; AT1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
63TGTGDFLKAPQSFRAubiquitination[1, 2]
135LVDAVYVKNFGRRKSubiquitination[2, 3, 4, 5]
378QPLNTFYKAMPYRLLubiquitination[1]
497PDAVELCKKLGGSCVubiquitination[4]
498DAVELCKKLGGSCVTubiquitination[4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Probable acetyl-CoA transporter necessary for O- acetylation of gangliosides. 
Sequence Annotation
 MOD_RES 42 42 Phosphoserine (By similarity).
 CARBOHYD 103 103 N-linked (GlcNAc...) (Potential).  
Keyword
 Cataract; Complete proteome; Deafness; Disease mutation; Endoplasmic reticulum; Glycoprotein; Hereditary spastic paraplegia; Membrane; Neurodegeneration; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 549 AA 
Protein Sequence
MSPTISHKDS SRQRRPGNFS HSLDMKSGPL PPGGWDDSHL DSAGREGDRE ALLGDTGTGD 60
FLKAPQSFRA ELSSILLLLF LYVLQGIPLG LAGSIPLILQ SKNVSYTDQA FFSFVFWPFS 120
LKLLWAPLVD AVYVKNFGRR KSWLVPTQYI LGLFMIYLST QVDRLLGNTD DRTPDVIALT 180
VAFFLFEFLA ATQDIAVDGW ALTMLSRENV GYASTCNSVG QTAGYFLGNV LFLALESADF 240
CNKYLRFQPQ PRGIVTLSDF LFFWGTVFLI TTTLVALLKK ENEVSVVKEE TQGITDTYKL 300
LFAIIKMPAV LTFCLLILTA KIGFSAADAV TGLKLVEEGV PKEHLALLAV PMVPLQIILP 360
LIISKYTAGP QPLNTFYKAM PYRLLLGLEY ALLVWWTPKV EHQGGFPIYY YIVVLLSYAL 420
HQVTVYSMYV SIMAFNAKVS DPLIGGTYMT LLNTVSNLGG NWPSTVALWL VDPLTVKECV 480
GASNQNCRTP DAVELCKKLG GSCVTALDGY YVESIICVFI GFGWWFFLGP KFKKLQDEGS 540
SSWKCKRNN 549 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; TAS:ProtInc.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0008521; F:acetyl-CoA transporter activity; TAS:ProtInc.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0055085; P:transmembrane transport; TAS:Reactome. 
Interpro
 IPR024371; Acetyl-CoA_trnpstr_1.
 IPR004752; AmpG_permease/AT-1.
 IPR016196; MFS_dom_general_subst_transpt. 
Pfam
 PF13000; Acatn 
SMART
  
PROSITE
  
PRINTS