CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006627
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 tRNA (guanine-N(1)-)-methyltransferase 
Protein Synonyms/Alias
 M1G-methyltransferase; tRNA [GM37] methyltransferase 
Gene Name
 trmD 
Gene Synonyms/Alias
 STM2674 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
83AAAGEGAKVIYLSPQacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Specifically methylates guanosine-37 in various tRNAs (By similarity). 
Sequence Annotation
 REGION 133 138 S-adenosyl-L-methionine binding (By
 BINDING 113 113 S-adenosyl-L-methionine; via amide  
Keyword
 Complete proteome; Cytoplasm; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase; tRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 255 AA 
Protein Sequence
MFIGIVSLFP EMFRAITDYG VTGRAVKKGL LNIQSWSPRD FAHDRHRTVD DRPYGGGPGM 60
LMMVQPLRDA IHAAKAAAGE GAKVIYLSPQ GRKLDQAGVS ELATNQKLIL VCGRYEGVDE 120
RVIQTEIDEE WSIGDYVLSG GELPAMTLID SVARFIPGVL GHEASAIEDS FADGLLDCPH 180
YTRPEVLEGM EVPPVLLSGN HAEIRRWRLK QSLGRTWLRR PELLENLALT EEQARLLAEF 240
KTEHAQQQHK HDGMA 255 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0052906; F:tRNA (guanine(37)-N(1))-methyltransferase activity; IEA:EC. 
Interpro
 IPR016009; tRNA_m1G_MeTrfase.
 IPR002649; tRNA_m1G_MeTrfase_bac.
 IPR023148; tRNA_m1G_MeTrfase_C. 
Pfam
 PF01746; tRNA_m1G_MT 
SMART
  
PROSITE
  
PRINTS