UniProt Accession

 ANPRC_HUMAN; P17342; A2RRD1; B4DT84; E7EPG9 

Genbank Protein ID

 X52282; M59305; AF025998; AK300094; AC008766; AC026703; CH471118; BC131540 

Genbank Nucleotide ID

 CAA36523.1; AAA51734.1; AAB88801.1; BAG61896.1; EAX10799.1; AAI31541.1 

Protein Name

 Atrial natriuretic peptide receptor 3 

Protein Synonyms/Alias

 Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor type C; ANP-C; ANPR-C; NPR-C 

Gene Name

 NPR3 

Gene Synonyms/Alias

 ANPRC; C5orf23; NPRC 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
456	KYPWGPLKLRIDENR	ubiquitination	[1]

Reference

 [1] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. 

Sequence Annotation

 BINDING 106 106 Chloride.
 BINDING 135 135 Chloride; via amide nitrogen.
 BINDING 136 136 Chloride; via amide nitrogen.
 CARBOHYD 86 86 N-linked (GlcNAc...) (complex).
 CARBOHYD 293 293 N-linked (GlcNAc...) (high mannose).
 CARBOHYD 394 394 N-linked (GlcNAc...) (complex).
 DISULFID 108 136
 DISULFID 213 261
 DISULFID 473 473 Interchain.  

Keyword

 3D-structure; Alternative splicing; Chloride; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 541 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; IC:BHF-UCL.
 GO:0008528; F:G-protein coupled peptide receptor activity; ISS:BHF-UCL.
 GO:0016941; F:natriuretic peptide receptor activity; IDA:UniProtKB.
 GO:0017046; F:peptide hormone binding; ISS:BHF-UCL.
 GO:0007193; P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0007194; P:negative regulation of adenylate cyclase activity; IEA:Compara.
 GO:0002158; P:osteoclast proliferation; ISS:UniProtKB.
 GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0051000; P:positive regulation of nitric-oxide synthase activity; ISS:BHF-UCL.
 GO:0035810; P:positive regulation of urine volume; ISS:UniProtKB.
 GO:0008217; P:regulation of blood pressure; ISS:UniProtKB.
 GO:0033688; P:regulation of osteoblast proliferation; ISS:UniProtKB.
 GO:0001501; P:skeletal system development; ISS:UniProtKB. 

Interpro

 IPR001828; ANF_lig-bd_rcpt.
 IPR001170; Ntpep_rcpt. 

Pfam

 PF01094; ANF_receptor 

SMART

  

PROSITE

 PS00458; ANF_RECEPTORS 

PRINTS

 PR00255; NATPEPTIDER.