CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013299
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ADP-ribosylation factor GTPase-activating protein 3 
Protein Synonyms/Alias
 ARF GAP 3 
Gene Name
 Arfgap3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
14QDILAIFKRLRSVPTacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity). 
Sequence Annotation
 DOMAIN 10 126 Arf-GAP.
 ZN_FING 25 48 C4-type.
 MOD_RES 232 232 Phosphoserine (By similarity).
 MOD_RES 332 332 Phosphoserine (By similarity).
 MOD_RES 379 379 Phosphoserine (By similarity).
 MOD_RES 462 462 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Cytoplasm; ER-Golgi transport; Golgi apparatus; GTPase activation; Membrane; Metal-binding; Phosphoprotein; Protein transport; Reference proteome; Transport; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 525 AA 
Protein Sequence
MGDPSKQDIL AIFKRLRSVP TNKVCFDCGA KNPSWASISY GVFLCIDCSG SHRSLGVHLS 60
FIRSTELDSN WSWFQLRCMQ VGGNANASSF FHQHGCATKD TNAKYNSRAA QLYREKIKTL 120
ATQATRRHGT DLWLDSCAAP PASPPPKEED FFASHASLEV SGATQASAQP EPASSTPWGL 180
ETTPEKHEGG PGQGPSVEGL NTPGKTAPAE VSSIIKKKPN QAKKGLGAKK GSLGAQKLTN 240
TSFTEIEKQA QAVDKRKEQE DLARGTPKEE SIVSSLRLAY KDLEIHKKQD ERLNLSGQKK 300
AEAERLGMGF GSCRGGISHS VTSDMQTIEQ ESPTLAKPRR KYQEDPEDSY FSSSSKWSEQ 360
SSSRYFDDPM ELRSSHFSSW DDSADSYWKK DSSRDPEPAT KSTGSSDRPS SRRKPEYEPV 420
GNTDEAQKKF GNVKAISSDM YFGIQSQTDF ETRARLERLS TSSSISSADL FDEQRKQTTG 480
NYNLSNVLPN APDMAQFKQG VRSVAGKLSV FANGVMTSIQ DRYGS 525 
Gene Ontology
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW. 
Interpro
 IPR001164; ArfGAP. 
Pfam
 PF01412; ArfGap 
SMART
 SM00105; ArfGap 
PROSITE
 PS50115; ARFGAP 
PRINTS
 PR00405; REVINTRACTNG.