UniProt Accession

 CD79A_HUMAN; P11912; A0N775; Q53FB8 

Genbank Protein ID

 S46706; M80462; M74721; S75217; M86921; U05259; S79248; X83540; AK223371; X13451 

Genbank Nucleotide ID

 AAB23558.1; AAA59556.1; AAA60270.1; AAB20812.1; AAA59557.1; AAA20495.1; AAC60653.1; CAA58523.1; BAD97091.1; CAA31802.1 

Protein Name

 B-cell antigen receptor complex-associated protein alpha chain 

Protein Synonyms/Alias

 Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein; CD79a 

Gene Name

 CD79A 

Gene Synonyms/Alias

 IGA; MB1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
141	LDMGEGTKNRIITAE	ubiquitination	[1]
225	IGDVQLEKP******	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells. 

Sequence Annotation

 DOMAIN 33 116 Ig-like C2-type.
 DOMAIN 177 205 ITAM.
 MOD_RES 188 188 Phosphotyrosine; by SRC-type Tyr-kinases
 MOD_RES 199 199 Phosphotyrosine; by SRC-type Tyr-kinases
 MOD_RES 204 204 Asymmetric dimethylarginine; by PRMT1 (By
 MOD_RES 210 210 Phosphotyrosine; by Tyr-kinases (By
 CARBOHYD 57 57 N-linked (GlcNAc...) (Potential).
 CARBOHYD 63 63 N-linked (GlcNAc...) (Potential).
 CARBOHYD 73 73 N-linked (GlcNAc...) (Potential).
 CARBOHYD 88 88 N-linked (GlcNAc...) (Potential).
 CARBOHYD 97 97 N-linked (GlcNAc...) (Potential).
 CARBOHYD 112 112 N-linked (GlcNAc...) (Potential).
 DISULFID 54 106 Potential.
 DISULFID 119 119 Interchain (with C-136 in beta chain)  

Keyword

 3D-structure; Adaptive immunity; Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain; Membrane; Methylation; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 226 AA 

Protein Sequence

Gene Ontology

 GO:0019815; C:B cell receptor complex; ISS:UniProtKB.
 GO:0009897; C:external side of plasma membrane; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045121; C:membrane raft; ISS:UniProtKB.
 GO:0005771; C:multivesicular body; ISS:UniProtKB.
 GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
 GO:0030183; P:B cell differentiation; ISS:UniProtKB.
 GO:0042100; P:B cell proliferation; ISS:UniProtKB.
 GO:0050853; P:B cell receptor signaling pathway; ISS:UniProtKB. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003598; Ig_sub2.
 IPR013106; Ig_V-set.
 IPR003110; Phos_immunorcpt_sig_ITAM. 

Pfam

 PF02189; ITAM
 PF07686; V-set 

SMART

 SM00408; IGc2
 SM00077; ITAM 

PROSITE

 PS50835; IG_LIKE
 PS51055; ITAM_1 

PRINTS