CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039772
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 SEC23-interacting protein 
Protein Synonyms/Alias
  
Gene Name
 SEC23IP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
118YLYDRIRKAAYWEEEubiquitination[1, 2]
137RRCTWFYKGDTDSRFubiquitination[2]
154YTEEFSEKLEAEYKKubiquitination[2, 3]
266DFRVVSLKLLRTHFKubiquitination[2, 4]
280KKSLDDGKVSRVEFLubiquitination[2]
392QKDLNLSKCPGPLAVubiquitination[3]
492IANFVEHKAAKLKKAubiquitination[2]
495FVEHKAAKLKKAASEubiquitination[2]
512AVAATSTKGQEQSAQubiquitination[1, 2]
604NYSLPTCKGFFNIYHubiquitination[2]
649KRLHLELKESLSRMGubiquitination[2]
660SRMGSDLKQGFISSLubiquitination[2]
668QGFISSLKSAWQTLNubiquitination[1]
699EKVANQIKEEEEKQVubiquitination[1]
720VESPDFSKDEDYLGKubiquitination[1, 3]
727KDEDYLGKVGMLNGGubiquitination[4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 789 AA 
Protein Sequence
MCPSSQSPRP PLLRPPCSYR EVPSSVQSPA QQQVPARPGA PSVQVPSPFL LQNQYEPVQP 60
HWFYCKEVEY KQLWMPFSVF DSLNLEEIYN SVQPDPESVV LGTDGGRYDV YLYDRIRKAA 120
YWEEEPAEVR RCTWFYKGDT DSRFIPYTEE FSEKLEAEYK KAVTTNQWHR RLEFPSGETI 180
VMHNPKVIVQ FQPSSVPDEW GTTQDGQTRP RVVKRGIDDN LDEIPDGEMP QVDHLVFVVH 240
GIGPVCDLRF RSIIECVDDF RVVSLKLLRT HFKKSLDDGK VSRVEFLPVH WHSSLGGDAT 300
GVDRNIKKIT LPSIGRFRHF TNETLLDILF YNSPTYCQTI VEKVGMEINH LHALFMSRNP 360
DFKGGVSVAG HSLGSLILFD ILSNQKDLNL SKCPGPLAVA NGVVKQLHFQ EKQMPEEPKL 420
TLDESYDLVV ENKEVLTLQE TLEALSLSEY FSTFEKEKID MESLLMCTVD DLKEMGIPLG 480
PRKKIANFVE HKAAKLKKAA SEKKAVAATS TKGQEQSAQK TKDMASLPSE SNEPKRKLPV 540
GACVSSVCVN YESFEVGAGQ VSVAYNSLDF EPEIFFALGS PIAMFLTIRG VDRIDENYSL 600
PTCKGFFNIY HPLDPVAYRL EPMIVPDLDL KAVLIPHHKG RKRLHLELKE SLSRMGSDLK 660
QGFISSLKSA WQTLNEFARA HTSSTQLQEE LEKVANQIKE EEEKQVVEAE KVVESPDFSK 720
DEDYLGKVGM LNGGRRIDYV LQEKPIESFN EYLFALQSHL CYWESEDTAL LLLKEIYRTM 780
NISPEQPQH 789 
Gene Ontology
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0046872; F:metal ion binding; IEA:InterPro. 
Interpro
 IPR004177; DDHD.
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR021129; SAM_type1. 
Pfam
 PF02862; DDHD
 PF00536; SAM_1 
SMART
 SM00454; SAM 
PROSITE
 PS51043; DDHD 
PRINTS