UniProt Accession

 GPAT4_HUMAN; Q86UL3; Q86V89 

Genbank Protein ID

 AF406612; AY358670; BC051377; BC061884 

Genbank Nucleotide ID

 AAP21893.1; AAQ89033.1; AAH51377.2; AAH61884.1 

Protein Name

 Glycerol-3-phosphate acyltransferase 4 

Protein Synonyms/Alias

 GPAT4; 1-acylglycerol-3-phosphate O-acyltransferase 6; 1-AGP acyltransferase 6; 1-AGPAT 6; Acyl-CoA:glycerol-3-phosphate acyltransferase 4; Lysophosphatidic acid acyltransferase zeta; LPAAT-zeta 

Gene Name

 AGPAT6 

Gene Synonyms/Alias

 GPAT4; UNQ551/PRO1108 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
93	TSLEEEIKEIRRSGS	ubiquitination	[1]
121	DIFYFCRKGMETIMD	ubiquitination	[1]
133	IMDDEVTKRFSAEEL	ubiquitination	[1]
426	LLWDGGLKREKVKDT	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs. 

Sequence Annotation

 MOTIF 248 253 HXXXXD motif.
 CARBOHYD 247 247 N-linked (GlcNAc...) (Potential).
 CARBOHYD 327 327 N-linked (GlcNAc...) (Potential).
 CARBOHYD 328 328 N-linked (GlcNAc...) (Potential).
 CARBOHYD 362 362 N-linked (GlcNAc...) (Potential).  

Keyword

 Acyltransferase; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Lipid biosynthesis; Lipid metabolism; Membrane; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 456 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0004366; F:glycerol-3-phosphate O-acyltransferase activity; IDA:UniProtKB.
 GO:0006637; P:acyl-CoA metabolic process; IDA:UniProtKB.
 GO:0016024; P:CDP-diacylglycerol biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0046339; P:diacylglycerol metabolic process; IEA:Compara.
 GO:0006631; P:fatty acid metabolic process; IEA:Compara.
 GO:0002071; P:glandular epithelial cell maturation; IEA:Compara.
 GO:0007595; P:lactation; ISS:UniProtKB.
 GO:0006654; P:phosphatidic acid biosynthetic process; TAS:Reactome.
 GO:0006656; P:phosphatidylcholine biosynthetic process; IDA:UniProtKB.
 GO:0040014; P:regulation of multicellular organism growth; IEA:Compara.
 GO:0019432; P:triglyceride biosynthetic process; ISS:UniProtKB. 

Interpro

 IPR002123; Plipid/glycerol_acylTrfase. 

Pfam

 PF01553; Acyltransferase 

SMART

 SM00563; PlsC 

PROSITE

  

PRINTS