| Tag | Content |
|---|
| CPLM ID | CPLM-004509 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cyclic AMP-dependent transcription factor ATF-2 |
Protein Synonyms/Alias | cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; MXBP protein; cAMP response element-binding protein CRE-BP1 |
Gene Name | Atf2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 391 | RNEVAQLKQLLLAHK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'- GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex. |
Sequence Annotation | DOMAIN 334 397 bZIP.
ZN_FING 7 31 C2H2-type.
REGION 336 356 Basic motif (By similarity).
REGION 362 390 Leucine-zipper (By similarity).
MOD_RES 51 51 Phosphothreonine; by MAPK11 and MAPK14.
MOD_RES 53 53 Phosphothreonine; by MAPK1, MAPK3,
MOD_RES 72 72 Phosphoserine (By similarity).
MOD_RES 94 94 Phosphoserine.
MOD_RES 98 98 Phosphothreonine (By similarity).
MOD_RES 310 310 Phosphoserine (By similarity). |
Keyword | Activator; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 487 AA |
Protein Sequence | MSDDKPFLCT APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RNDSVIVADQ TPTPTRFLKN 60
CEEVGLFNEL ASPFENEFKK ASEDDIKKMP LDLSPLATPI IRSKIEEPSV VETTHQDSPL 120
PHPESTTSDE KEVPLAQTAQ PTSAIVRPAS LQVPNVLLTS SDSSVIIQQA VPSPTSSTVI 180
TQAPSSNRPI VPVPGPFPLL LHLPNGQTMP VAIPASITSS NVHVPAAVPL VRPVTMVPSV 240
PGIPGPSSPQ PVQSEAKMRL KAALTQQHPP VTNGDTVKGH GSGLVRTQSE ESRPQSLQQP 300
ATSTTETPAS PAHTTPQTQN TSGRRRRAAN EDPDEKRRKF LERNRAAASR CRQKRKVWVQ 360
SLEKKAEDLS SLNGQLQSEV TLLRNEVAQL KQLLLAHKDC PVTAMQKKSG YHTADKDDSS 420
EDLSVPSSPH TEAIQHSSVS TSNGVSSTSK AEAVATSVLT QMADQSTEPA LSQIVMAPPS 480
QAQPSGS 487 |
Gene Ontology | GO:0016020; C:membrane; IDA:MGI. GO:0005634; C:nucleus; IDA:MGI. GO:0035497; F:cAMP response element binding; IEA:Compara. GO:0008140; F:cAMP response element binding protein binding; IEA:Compara. GO:0003682; F:chromatin binding; IDA:MGI. GO:0003677; F:DNA binding; IDA:MGI. GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:MGI. GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Compara. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0060612; P:adipose tissue development; IGI:MGI. GO:0045444; P:fat cell differentiation; IGI:MGI. GO:0003151; P:outflow tract morphogenesis; IMP:MGI. GO:0032915; P:positive regulation of transforming growth factor beta2 production; IMP:MGI. GO:0006970; P:response to osmotic stress; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |