CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007986
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aminomethyltransferase, mitochondrial 
Protein Synonyms/Alias
 Glycine cleavage system T protein; GCVT; Glycine decarboxylase complex subunit T 
Gene Name
 GCV1 
Gene Synonyms/Alias
 YDR019C; YD9335.05C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
80LSGPHSVKFLQRVTPacetylation[1]
189TAPGKDLKELFFGQRacetylation[1]
202QRHEFALKDGSLVQIacetylation[1]
292RRDLVDQKYWFNGYAacetylation[1]
399LVPTHYYKQ******acetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 The glycine cleavage system (glycine decarboxylase complex) catalyzes the degradation of glycine. 
Sequence Annotation
 BINDING 221 221 Substrate (By similarity).
 BINDING 250 250 Substrate (By similarity).
 BINDING 397 397 Substrate (By similarity).  
Keyword
 Aminotransferase; Complete proteome; Mitochondrion; Reference proteome; Transferase; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 400 AA 
Protein Sequence
MSIIKKIVFK RFNSTLKKTA LHDLHVSLGG TMVPYAGYSM PVLYKGQTHI ESHNWTRTNA 60
GLFDVSHMLQ SKLSGPHSVK FLQRVTPTDF NALPVGSGTL SVLLNPQGGV VDDTIITKEN 120
DDNEFYIVTN AGCAERDTEF FHDELQNGST LDCQWKIIEG RSLLALQGPK AKDVLEPLLS 180
KTAPGKDLKE LFFGQRHEFA LKDGSLVQIA RGGYTGEDGF EISIANEKAV EFAEQLLANP 240
VMKPIGLAAR DSLRLEAGMC LYGHELDESI TPVEAALNWV ISKSRRDLVD QKYWFNGYAK 300
IMDQLNNKTY SKVRVGFKYL KKGPAARNGV KIFLPDAETE VGLVTSGSAS PTLNNINIGQ 360
AYVQKGYHKK GTKLLVQVRN KFYPIELAKM PLVPTHYYKQ 400 
Gene Ontology
 GO:0005960; C:glycine cleavage complex; ISS:SGD.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0004047; F:aminomethyltransferase activity; IEA:EC.
 GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
 GO:0006546; P:glycine catabolic process; IC:SGD.
 GO:0006730; P:one-carbon metabolic process; IMP:SGD. 
Interpro
 IPR013977; GCV_T_C.
 IPR006222; GCV_T_N.
 IPR006223; GcvT.
 IPR027266; TrmE/GcvT_dom1. 
Pfam
 PF01571; GCV_T
 PF08669; GCV_T_C 
SMART
  
PROSITE
  
PRINTS