CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043891
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein arginine N-methyltransferase 1 
Protein Synonyms/Alias
 Protein arginine methyltransferase 1, isoform CRA_b 
Gene Name
 PRMT1 
Gene Synonyms/Alias
 hCG_21109 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
113AAKAGARKVIGIECSubiquitination[1]
131DYAVKIVKANKLDHVubiquitination[1]
134VKIVKANKLDHVVTIubiquitination[1, 2]
143DHVVTIIKGKVEEVEubiquitination[1]
145VVTIIKGKVEEVELPubiquitination[1]
183TVLYARDKWLAPDGLubiquitination[1]
233CIKDVAIKEPLVDVVubiquitination[1, 2]
243LVDVVDPKQLVTNACubiquitination[2]
253VTNACLIKEVDIYTVubiquitination[1]
276SPFCLQVKRNDYVHAubiquitination[1]
342IGMRPNAKNNRDLDFubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Methyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 371 AA 
Protein Sequence
MAAAEAANCI MENFVATLAN GMSLQPPLEE VSCGQAESSE KPNAEDMTSK DYYFDSYAHF 60
GIHEEMLKDE VRTLTYRNSM FHNRHLFKDK VVLDVGSGTG ILCMFAAKAG ARKVIGIECS 120
SISDYAVKIV KANKLDHVVT IIKGKVEEVE LPVEKVDIII SEWMGYCLFY ESMLNTVLYA 180
RDKWLAPDGL IFPDRATLYV TAIEDRQYKD YKIHWWENVY GFDMSCIKDV AIKEPLVDVV 240
DPKQLVTNAC LIKEVDIYTV KVEDLTFTSP FCLQVKRNDY VHALVAYFNI EFTRCHKRTG 300
FSTSPESPYT HWKQTVFYME DYLTVKTGEE IFGTIGMRPN AKNNRDLDFT IDLDFKGQLC 360
ELSCSTDYRM R 371 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0016275; F:[cytochrome c]-arginine N-methyltransferase activity; IEA:Compara.
 GO:0008469; F:histone-arginine N-methyltransferase activity; IEA:Compara.
 GO:0035242; F:protein-arginine omega-N asymmetric methyltransferase activity; IEA:Compara.
 GO:0035241; F:protein-arginine omega-N monomethyltransferase activity; IEA:Compara.
 GO:0030519; F:snoRNP binding; IEA:Compara.
 GO:0034969; P:histone arginine methylation; IEA:GOC.
 GO:0001701; P:in utero embryonic development; IEA:Compara. 
Interpro
 IPR025799; Arg_MeTrfase.
 IPR025714; Methyltranfer_dom. 
Pfam
 PF13847; Methyltransf_31 
SMART
  
PROSITE
  
PRINTS