UniProt Accession

 A2AH25_MOUSE; A2AH25 

Genbank Protein ID

 AL691489; AL714023 

Genbank Nucleotide ID

  

Protein Name

 Rho GTPase-activating protein 1 

Protein Synonyms/Alias

  

Gene Name

 Arhgap1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
71	KLASIDEKNWPSDEM	ubiquitination	[1]
99	PEPVTHLKWDDPYYD	acetylation	[2]
252	GIPRQVLKYDDFLKS	acetylation	[3]
252	GIPRQVLKYDDFLKS	ubiquitination	[1]
451	KDAAITLKAINPINT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 479 AA 

Protein Sequence

Gene Ontology

 GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0001726; C:ruffle; IDA:MGI.
 GO:0030675; F:Rac GTPase activator activity; IDA:MGI.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:Compara. 

Interpro

 IPR001251; CRAL-TRIO_dom.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom. 

Pfam

 PF00620; RhoGAP 

SMART

 SM00324; RhoGAP
 SM00516; SEC14 

PROSITE

 PS50191; CRAL_TRIO
 PS50238; RHOGAP 

PRINTS