CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038245
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Afadin 
Protein Synonyms/Alias
  
Gene Name
 Mllt4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
90MRMLSSPKYSLYEVHubiquitination[1]
258RIYADSLKPNIPYKTubiquitination[1]
315HSDERGAKEIILDDDubiquitination[1]
336FREWPSDKGILVFQLacetylation[2]
336FREWPSDKGILVFQLubiquitination[1]
1013EIITVTLKKQNGMGLubiquitination[1]
1042IYVKSVVKGGAADVDubiquitination[1]
1237YFTFPASKSQDRMAPubiquitination[1]
1337TPASTLTKSGPGRWKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1663 AA 
Protein Sequence
MSAGGRDEER RKLADIIHHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK AAGNFATKCI 60
RVSSTATTQD VIETLAEKFR PDMRMLSSPK YSLYEVHVSG ERRLDIDEKP LVVQLNWNKD 120
DREGRFVLKN ENDAIPAKKA QSNGPEKQEK EGVIQNFKRT LSKKEKKEKK KKEKEALRQA 180
SDKEERPSQG DDSENSRLAA EVYKDMPETS FTRTISNPEV VMKRRRQQKL EKRMQEFRSS 240
DGRPDSGGTL RIYADSLKPN IPYKTILLST TDTADFAVAE SLEKYGLEKE NPKDYCIARV 300
MLPPGAQHSD ERGAKEIILD DDECPLQIFR EWPSDKGILV FQLKRRPPDY IPKKMKKHVE 360
GKSLKGKDRA DGSGYGSALP PEKLPYLVEL SPGRRNHFAY YSYHTYEDGS DSRDKPKLYR 420
LQLSVTEVGT EKFDDNSIQL FGPGIQPHHC DLTNMDGVVT VTPRSMDAET YVDGQRISET 480
TMLQSGMRLQ FGTSHVFKFV DPIQDHVLSK RSVDGGLMVK GPRHKPGAVQ ETTFELGGDV 540
HSGTALPASR STTRLDSDRV SSASSTAERG MVKPMIRLDQ EQEYRRRENR TQDATGPELI 600
LPASIEFRES SEDSFLSAII NYTNSSTVHF KLSPTYVLYM ACRYVLSSQH RPDISPTERT 660
HKAIAVVNKM VSMMEGVIQK QKNIAGALAF WMANASELLN FIKQDRDLSR ITLDAQDVLA 720
HLVQMAFKYL VHCLQSELNN YMPAFLDDPE ENSLQRPKID DVLHTLTGAM SLLRRCRVNA 780
ALTIQLFSQL FHFINMWLFN RLVTDPDSGL CSHYWGAIIR QQLGHIEAWA EKQGLELAAD 840
CHLSRIVQAT TLLTMDKYVP DDIPNINSTC FKLNSLQLQA LLQNYHCAPD EPFIPTDLIE 900
NVVAVAENTA DELARSDGRD VQLEEDPDLQ LPFLLPEDGY SCDVVRNIPN GLQEFLDPLC 960
QRGFCRLVPH TRSPGTWTIY FEGADYESHL MRENAELAQP LRKEPEIITV TLKKQNGMGL 1020
SIVAAKGAGQ DKLGIYVKSV VKGGAADVDG RLAAGDQLLS VDGRSLVGLS QERAAELMTR 1080
TSSVVTLEVA KQGAIYHGLA TLLNQPSPMM QRISDRRGSG KPRPKSEGFE LYNNSAQNGS 1140
PESPQMPWTE YSEPKKLPGD DRLMKNRADH RSSPNVANQP PSPGGKGPYT SGTAAKITSV 1200
STGNLCTEEQ SPPPRPEAYP IPTQTYTREY FTFPASKSQD RMAPPQSQWP NYEEKPHVHT 1260
ESNHSSIAIQ RVTRSQEELR EEKVYQLERH RVEAGMDRKC DSDMWINQSS SVESSTSSQE 1320
HLNHSSKSVT PASTLTKSGP GRWKTPAAVL PTPVAVSQPI RTDLPPPPPP PPVHYTSEFD 1380
GIPMDLPLPP PPANQAGPQS AQVAAAEWKK REEHQRWYEK EKARLEEERE RKRREQERKL 1440
GQMRSQTLNP ASFSPLATQA KPEKPSTLQR PQETVIRELQ PQQQPRTIER KDLQYITISK 1500
EELSSGDSLS PDPWKRDARE KLEKQQQMHI VDMLSKEIHE LQNKVDRTAE ESDRLRKLML 1560
EWQFQKRLQE SKQKDEDDDE EEDDDVDTML IMQRLEAERR ARQTAMPAIS VLDLMQDEER 1620
RRQQQLEEMR KREAEDRVRQ EEDGRHQEEE RVKRDAEEKV MVL 1663 
Gene Ontology
 GO:0045177; C:apical part of cell; IDA:MGI.
 GO:0005913; C:cell-cell adherens junction; IDA:MGI.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR018444; Dil_domain.
 IPR002710; Dilute.
 IPR000253; FHA_dom.
 IPR001478; PDZ.
 IPR000159; Ras-assoc.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF01843; DIL
 PF00498; FHA
 PF00595; PDZ
 PF00788; RA 
SMART
 SM00240; FHA
 SM00228; PDZ
 SM00314; RA 
PROSITE
 PS51126; DILUTE
 PS50106; PDZ
 PS50200; RA 
PRINTS