CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039794
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Gelsolin 
Protein Synonyms/Alias
  
Gene Name
 GSN 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
202LKATQVSKGIRDNERubiquitination[1]
259RKLAKLYKVSNGAGTubiquitination[1]
317EERKAALKTASDFITubiquitination[1]
325TASDFITKMDYPKQTubiquitination[1, 2]
330ITKMDYPKQTQVSVLubiquitination[1, 3]
541RAVEVLPKAGALNSNubiquitination[2]
605FWEALGGKAAYRTSPubiquitination[1]
685TEALTSAKRYIETDPubiquitination[1, 3]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 739 AA 
Protein Sequence
MPLCTPNSMV VEHPEFLKAG KEPGLQIWRV EKFDLVPVPT NLYGDFFTGD AYVILKTVQL 60
RNGNLQYDLH YWLGNECSQD ESGAAAIFTV QLDDYLNGRA VQHREVQGFE SATFLGYFKS 120
GLKYKKGGVA SGFKHVVPNE VVVQRLFQVK GRRVVRATEV PVSWESFNNG DCFILDLGNN 180
IHQWCGSNSN RYERLKATQV SKGIRDNERS GRARVHVSEE GTEPEAMLQV LGPKPALPAG 240
TEDTAKEDAA NRKLAKLYKV SNGAGTMSVS LVADENPFAQ GALKSEDCFI LDHGKDGKIF 300
VWKGKQANTE ERKAALKTAS DFITKMDYPK QTQVSVLPEG GETPLFKQFF KNWRDPDQTD 360
GLGLSYLSSH IANVERVPFD AATLHTSTAM AAQHGMDDDG TGQKQIWRIE GSNKVPVDPA 420
TYGQFYGGDS YIILYNYRHG GRQGQIIYNW QGAQSTQDEV AASAILTAQL DEELGGTPVQ 480
SRVVQGKEPA HLMSLFGGKP MIIYKGGTSR EGGQTAPAST RLFQVRANSA GATRAVEVLP 540
KAGALNSNDA FVLKTPSAAY LWVGTGASEA EKTGAQELLR VLRAQPVQVA EGSEPDGFWE 600
ALGGKAAYRT SPRLKDKKMD AHPPRLFACS NKIGRFVIEE VPGELMQEDL ATDDVMLLDT 660
WDQVFVWVGK DSQEEEKTEA LTSAKRYIET DPANRDRRTP ITVVKQGFEP PSFVGWFLGW 720
DDDYWSVDPL DRAMAELAA 739 
Gene Ontology
  
Interpro
 IPR007123; Gelsolin_dom.
 IPR007122; Villin/Gelsolin. 
Pfam
 PF00626; Gelsolin 
SMART
 SM00262; GEL 
PROSITE
  
PRINTS
 PR00597; GELSOLIN.