CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000861
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein NipSnap homolog 1 
Protein Synonyms/Alias
 NipSnap1 
Gene Name
 Nipsnap1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
37GAVRFYSKDSEGSWFacetylation[1]
51FRSLFVHKVDPRKDAacetylation[1, 2, 3]
65AHSTLLSKKETSNLYacetylation[1, 3]
66HSTLLSKKETSNLYKacetylation[1, 4]
73KETSNLYKIQFHNVKacetylation[1, 2, 3]
80KIQFHNVKPECLDAYacetylation[1, 2, 3]
141ALMDCMNKLKNNKEYacetylation[1, 2, 3]
143MDCMNKLKNNKEYLEacetylation[1, 3]
146MNKLKNNKEYLEFRKacetylation[1, 2, 3, 4, 5, 6]
146MNKLKNNKEYLEFRKsuccinylation[6]
191IYELRTYKLKPGTMIacetylation[1, 2, 3, 6]
191IYELRTYKLKPGTMIsuccinylation[6]
193ELRTYKLKPGTMIEWacetylation[1, 2, 3, 6]
193ELRTYKLKPGTMIEWsuccinylation[6]
279SRIMIPLKISPLQ**acetylation[1, 3, 4]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [5] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]
 [6] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
 MOD_RES 146 146 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Direct protein sequencing; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 284 AA 
Protein Sequence
MAPRLCIISA AARRLFTKPR PRAGDLAAAG AVRFYSKDSE GSWFRSLFVH KVDPRKDAHS 60
TLLSKKETSN LYKIQFHNVK PECLDAYNSL TEAVLPKLHL DEDYPCSLVG NWNTWYGEQD 120
QAVHLWRFSG GYPALMDCMN KLKNNKEYLE FRKERSKMLL SRRNQLLLEF SFWNEPQPRA 180
GPNIYELRTY KLKPGTMIEW GNNWARAIKY RQENQEAVGG FFSQIGELYV VHHLWAYKDL 240
QSREETRNAA WRKRGWDENV YYTVPLVRHM ESRIMIPLKI SPLQ 284 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0097060; C:synaptic membrane; IDA:MGI.
 GO:0042165; F:neurotransmitter binding; IDA:MGI.
 GO:0019233; P:sensory perception of pain; IMP:MGI. 
Interpro
 IPR011008; Dimeric_a/b-barrel.
 IPR012577; NIPSNAP. 
Pfam
 PF07978; NIPSNAP 
SMART
  
PROSITE
  
PRINTS