CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004942
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Periodic tryptophan protein 1 
Protein Synonyms/Alias
  
Gene Name
 PWP1 
Gene Synonyms/Alias
 YLR196W; L8167.10 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
502GGVNKVLKLWDVFTNubiquitination[1]
517RSVRKSFKSELENVQacetylation[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
  
Sequence Annotation
 REPEAT 207 252 WD 1.
 REPEAT 284 324 WD 2.
 REPEAT 329 369 WD 3.
 REPEAT 376 414 WD 4.
 REPEAT 420 461 WD 5.
 REPEAT 472 514 WD 6.
 MOD_RES 52 52 Phosphoserine.
 MOD_RES 131 131 Phosphoserine.  
Keyword
 Complete proteome; Phosphoprotein; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 576 AA 
Protein Sequence
MISATNWVPR GFSSEFPEKY VLDDEEVERI NQLAQLNLDD AKATLEEAEG ESGVEDDAAT 60
GSSNKLKDQL DIDDDLKEYN LEEYDDEEIA DNEGGKDVSM FPGLSNDSDV KFHEGEKGED 120
PYISLPNQED SQEEKQELQV YPSDNLVLAA RTEDDVSYLD IYVYDDGAGF HSSDIPVEEG 180
DEADPDVARG LVRDPALYVH HDLMLPAFPL CVEWLDYKVG SNSEEAANYA AIGTFDPQIE 240
IWNLDCVDKA FPDMILGEPL DNSMVSLKSK KKKKKSKTGH ITTHHTDAVL SMAHNKYFRS 300
VLASTSADHT VKLWDLNSGN AARSLASIHS NKNVSSSEWH MLNGSILLTG GYDSRVALTD 360
VRISDESQMS KYWSAMAGEE IETVTFASEN IILCGTDSGN VYSFDIRNNE NRKPVWTLKA 420
HDAGISTLCS NKFIPGMMST GAMGEKTVKL WKFPLDDATN TKGPSMVLSR DFDVGNVLTS 480
SFAPDIEVAG TMVIGGVNKV LKLWDVFTNR SVRKSFKSEL ENVQARAKEE AQKIGKSSRI 540
ARKYTSNDNP DTVITIDDQG EDEEEREGGD EHDDMA 576 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0006364; P:rRNA processing; IMP:SGD. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS