UniProt Accession

 B1AK13_HUMAN; B1AK13; A6NMQ0 

Genbank Protein ID

 AL031295; AL590728; AK122801; CH471134 

Genbank Nucleotide ID

 BAG53736.1; EAW95095.1 

Protein Name

 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (Hydroxymethylglutaricaciduria), isoform CRA_b 

Protein Synonyms/Alias

 Hydroxymethylglutaryl-CoA lyase, mitochondrial; cDNA FLJ16378 fis, clone TKIDN2016399, highly similar to Hydroxymethylglutaryl-CoA lyase, mitochondrial (EC 4.1.3.4) 

Gene Name

 HMGCL 

Gene Synonyms/Alias

 hCG_37683 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
23	RDGLQNEKNIVSTPV	acetylation	[1, 2, 3]
68	GDHTEVLKGIQKFPG	acetylation	[2, 3]
86	PVLTPNLKGFEAAVA	acetylation	[2]
112	ASELFTKKNINCSIE	acetylation	[3]

Reference

 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Lyase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 300 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0031406; F:carboxylic acid binding; IEA:Compara.
 GO:0000062; F:fatty-acyl-CoA binding; IEA:Compara.
 GO:0004419; F:hydroxymethylglutaryl-CoA lyase activity; IEA:InterPro.
 GO:0006637; P:acyl-CoA metabolic process; IEA:Compara.
 GO:0009790; P:embryo development; IEA:Compara.
 GO:0046951; P:ketone body biosynthetic process; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0007005; P:mitochondrion organization; IEA:Compara.
 GO:0070542; P:response to fatty acid; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0042594; P:response to starvation; IEA:Compara. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR027167; HMG-CoA_lyase.
 IPR000138; HMG_CoA_lyase_AS.
 IPR000891; PYR_CT. 

Pfam

 PF00682; HMGL-like 

SMART

  

PROSITE

 PS01062; HMG_COA_LYASE
 PS50991; PYR_CT 

PRINTS