CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028338
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 KIAA0999 protein 
Protein Synonyms/Alias
 Serine/threonine-protein kinase SIK3 
Gene Name
 KIAA0999 
Gene Synonyms/Alias
 SIK3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
16EIDRTIGKGNFAVVKubiquitination[1, 2]
41VAIKIIDKTQLDEENubiquitination[3]
50QLDEENLKKIFREVQubiquitination[3]
132NIVHRDLKAENLLLDubiquitination[3, 4]
221RARVLSGKFRIPFFMubiquitination[2]
257MEQICKHKWMKLGDAubiquitination[2]
260ICKHKWMKLGDADPNubiquitination[2]
279IAECQQLKEERQVDPubiquitination[2, 5]
578AASIQAFKAHLEKMGubiquitination[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1203 AA 
Protein Sequence
MPARIGYYEI DRTIGKGNFA VVKRATHLVT KAKVAIKIID KTQLDEENLK KIFREVQIMK 60
MLCHPHIIRL YQVMETERMI YLVTEYASGG EIFDHLVAHG RMAEKEARRK FKQIVTAVYF 120
CHCRNIVHRD LKAENLLLDA NLNIKIADFG FSNLFTPGQL LKTWCGSPPY AAPELFEGKE 180
YDGPKVDIWS LGVVLYVLVC GALPFDGSTL QNLRARVLSG KFRIPFFMST ECEHLIRHML 240
VLDPNKRLSM EQICKHKWMK LGDADPNFDR LIAECQQLKE ERQVDPLNED VLLAMEDMGL 300
DKEQTLQAEQ AGTAMNISVP QVQLINPENQ IVEPDGTLNL DSDEGEEPSP EALVRYLSMR 360
RHTVGVADPR TEVMEDLQKL LPGFPGVNPQ APFLQVAPNV NFMHNLLPMQ NLQPTGQLEY 420
KEQSLLQPPT LQLLNGMGPL GRRASDGGAN IQLHAQQLLK RPRGPSPLVT MTPAVPAVTP 480
VDEESSDGEP DQEAVQRYLA NRSKRHTLAM TNPTAEIPPD LQRQLGQQPF RSRVWPPHLV 540
PDQHRSTYKD SNTLHLPTER FSPVRRFSDG AASIQAFKAH LEKMGNNSSI KQLQQECEQL 600
QKMYGGQIDE RTLEKTQQQH MLYQQEQHHQ ILQQQIQDSI CPPQPSPPLQ AACENQPALL 660
THQLQRLRIQ PSSPPPNHPN NHLFRQPSNS PPPMSSAMIQ PHGAASSSQF QGLPSRSAIF 720
QQQPENCSSP PNVALTCLGM QQPAQSQQVT IQVQEPVDML SNMPGTAAGS SGRGISISPS 780
AGQMQMQHRT NLMATLSYGH RPLSKQLSAD SAEAHSAHQQ PPHYTTSALQ QALLSPTPPD 840
YTRHQQVPHI LQGLLSPRHS LTGHSDIRLP PTEFAQLIKR QQQQRQQQQQ QQQQQEYQEL 900
FRHMNQGDAG SLAPSLGGQS MTERQALSYQ NADSYHHHTS PQHLLQIRAQ ECVSQASSPT 960
PPHGYAHQPA LMHSESMEED CSCEGAKDGF QDSKSSSTLT KGCHDSPLLL STGGPGDPES 1020
LLGTVSHAQE LGIHPYGHQP TAAFSKNKVP SREPVIGNCM DRSSPGQAVE LPDHNGLGYP 1080
ARPSVHEHHR PRALQRHHTI QNSDDAYVQL DNLPGMSLVA GKALSSARMS DAVLSQSSLM 1140
GSQQFQDGEN EECGASLGGH EHPDLSDGSQ HLNSSCYPST CITDILLSYK HPEVSFSMEQ 1200
AGV 1203 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS