CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023370
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MAU2 chromatid cohesion factor homolog 
Protein Synonyms/Alias
 Cohesin loading complex subunit SCC4 homolog 
Gene Name
 CG4203 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
481RFLRETLKMANAEDLacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Required for association of the cohesin complex with chromatin during interphase. Plays a role in sister chromatid cohesion and normal progression through prometaphase (By similarity). 
Sequence Annotation
 REPEAT 453 486 TPR 1.
 REPEAT 493 526 TPR 2.  
Keyword
 Cell cycle; Cell division; Chromosome partition; Complete proteome; Mitosis; Nucleus; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 632 AA 
Protein Sequence
MSASTSTSTA ASQDACYISL LGLAEYFRTS QPPNIKKCIQ CLQALFTFMP PSKVEARTHL 60
QMGQILMAYT KNIDLARQHL EKAWSISEPL PNFDVKFDTA SLLAQLHLQT DRNSHQAKAM 120
LRRAVELSQN NVYWHCKLLL QLAQIHASDR EYSLASELLA VGAESADEAS ATYLKVLFLL 180
SRAMILMIER KTNDVLALLN SAGQIIDNNI PNPHQKEYLK VFFLVLQVCY YLALGQVKTV 240
KPSLKQLQMS IQTIMAPNWP SDEAIFGANQ LEMFVWLPKE QLYVLVYLVT VSHSMMAGYM 300
DKAQKYTEKA LTQIEKLKQQ EDKPILSVFK VILLEHIVMC RMVMGNRELA IREIAAARDV 360
CMAAPQRSLL RRHSAQLHCL IGLYSMSTNL FEHAERQFVV CVSETSERDL KLFANLNLAI 420
IYLRTKRDTD LKQILDAVST ENTHTYSSQA LMGGFYYVQG LHAFHKNSFH EAKRFLRETL 480
KMANAEDLNR LTSCSLVLLS HVFLSIGNSK ESMNMVTPAM QLASKIPDIH VQLWGSAILK 540
DLHRMSKDVQ HEKDAYANHV KYSENLIADQ RKCVQSAHHE LVNWFQGDPP VTSGPPAAPV 600
LLMPESSVTA SVPVIASTST AMQPAGQYGQ FY 632 
Gene Ontology
 GO:0000785; C:chromatin; ISS:UniProtKB.
 GO:0005654; C:nucleoplasm; ISS:UniProtKB.
 GO:0032116; C:SMC loading complex; ISS:UniProtKB.
 GO:0007411; P:axon guidance; ISS:FlyBase.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB. 
Interpro
 IPR019440; Cohesin_loading_factor.
 IPR011990; TPR-like_helical. 
Pfam
 PF10345; Cohesin_load 
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS