CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014526
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 26S protease regulatory subunit 6A 
Protein Synonyms/Alias
 26S proteasome AAA-ATPase subunit RPT5; Proteasome 26S subunit ATPase 3; Spermatogenic cell/sperm-associated Tat-binding protein homolog SATA; Tat-binding protein 1; TBP-1 
Gene Name
 Psmc3 
Gene Synonyms/Alias
 Tbp1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
53RLLDSEIKIMKSEVLacetylation[1]
53RLLDSEIKIMKSEVLubiquitination[2]
146LVDAEKLKPGDLVGVubiquitination[2]
211LPMNHKEKFENLGIQacetylation[1]
276RDAFALAKEKAPSIIubiquitination[2]
300TKRFDSEKAGDREVQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). 
Sequence Annotation
 NP_BIND 227 234 ATP (Potential).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 9 9 Phosphoserine (By similarity).  
Keyword
 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Nucleotide-binding; Nucleus; Phosphoprotein; Proteasome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 439 AA 
Protein Sequence
MNLLPTPESP VTRQEKMATV WDEAEQDGIG EEVLKMSTEE IVQRTRLLDS EIKIMKSEVL 60
RVTHELQAMK DKIKENSEKI KVNKTLPYLV SNVIELLDVD PNDQEEDGAN IDLDSQRKGK 120
CAVIKTSTRQ TYFLPVIGLV DAEKLKPGDL VGVNKDSYLI LETLPTEYDS RVKAMEVDER 180
PTEQYSDIGG LDKQIQELVE AIVLPMNHKE KFENLGIQPP KGVLMYGPPG TGKTLLARAC 240
AAQTKATFLK LAGPQLVQMF IGDGAKLVRD AFALAKEKAP SIIFIDELDA IGTKRFDSEK 300
AGDREVQRTM LELLNQLDGF QPNTQVKVIA ATNRVDILDP ALLRSGRLDR KIEFPMPNEE 360
ARARIMQIHS RKMNVSPDVN YEELARCTDD FNGAQCKAVC VEAGMIALRR GATELTHEDY 420
MEGILEVQAK KKANLQYYA 439 
Gene Ontology
 GO:0000932; C:cytoplasmic mRNA processing body; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
 GO:0022624; C:proteasome accessory complex; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0001824; P:blastocyst development; IEA:Compara.
 GO:0030163; P:protein catabolic process; IEA:InterPro. 
Interpro
 IPR005937; 26S_Psome_P45.
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00004; AAA 
SMART
 SM00382; AAA 
PROSITE
 PS00674; AAA 
PRINTS