CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030285
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 E3 ubiquitin-protein ligase 
Protein Synonyms/Alias
  
Gene Name
 Nedd4 
Gene Synonyms/Alias
 mCG_8038 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
83DTRVVRVKVIAGIGLubiquitination[1]
92IAGIGLAKKDILGASubiquitination[1]
93AGIGLAKKDILGASDubiquitination[1]
130IKKSLNPKWNEEILFubiquitination[1]
186MERPYTFKDFVLHPRubiquitination[1]
206VKGYLRLKMTYLPKNubiquitination[1]
278ESRRTQWKRPSPDDDubiquitination[1]
429YYVDHNSKTTTWSKPubiquitination[1]
453IPAHLRGKTDSNDLGubiquitination[1]
484FFINHNIKKTQWEDPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Ligase; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 887 AA 
Protein Sequence
MSSDMAADES EAPVLSEDEV WEFCLDKTED GGGSPGSDVT DTCEPPCGCW ELNPNSLEEE 60
HVLFTADPYL ELHNDDTRVV RVKVIAGIGL AKKDILGASD PYVRVTLYDP MSGILTSVQT 120
KTIKKSLNPK WNEEILFRVL PQRHRILFEV FDENRLTRDD FLGQVDVPLY PLPTENPRME 180
RPYTFKDFVL HPRSHKSRVK GYLRLKMTYL PKNGSEDENA DQAEELEPGW VVLDQPDAAT 240
HLPHPPEPSP LPPGWEERQD VLGRTYYVNH ESRRTQWKRP SPDDDLTDED NDDMQLQAQR 300
AFTTRRQISE DVDGPDNRES PENWEIVRED ENTEYSGQAV QSPPSGHIDV QTHLAEEFNT 360
RLAVCGNPAT SQPVTSSNHS SRGGSLQTCI FEEQPTLPVL LPTSSGLPPG WEEKQDDRGR 420
SYYVDHNSKT TTWSKPTMQD DPRSKIPAHL RGKTDSNDLG PLPPGWEERT HTDGRVFFIN 480
HNIKKTQWED PRLQNVAITG PAVPYSRDYK RKYEFFRRKL KKQTDIPNKF EMKLRRANIL 540
EDSYRRIMGV KRADLLKARL WIEFDGEKGL DYGGVAREWF FLISKEMFNP YYGLFEYSAT 600
DNYTLQINPN SGLCNEDHLS YFKFIGRVAG MAVYHGKLLD GFFIRPFYKM MLQKLITLHD 660
MESVDSEYYS SLRWILENDP TELDLRFIID EELFGQTHQH ELKTGGSEIV VTNKNKKEYI 720
YLVIQWRFVN RIQKQMAAFK EGFFELIPQD LIKIFDENEL ELLMCGLGDV DVNDWREHTK 780
YKNGYSMNHQ VIHWFWKAVW MMDSEKRIRL LQFVTGTSRV PMNGFAELYG SNGPQSFTVE 840
QWGTPDKLPR AHTCFNRLDL PPYESFDELW DKLQMAIENT QGFDGVD 887 
Gene Ontology
 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0000785; C:chromatin; IEA:Compara.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0000151; C:ubiquitin ligase complex; IPI:MGI.
 GO:0019871; F:sodium channel inhibitor activity; IDA:MGI.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.
 GO:0002250; P:adaptive immune response; IMP:MGI.
 GO:0048514; P:blood vessel morphogenesis; IMP:MGI.
 GO:0044111; P:development involved in symbiotic interaction; IEA:Compara.
 GO:0003197; P:endocardial cushion development; IMP:MGI.
 GO:0042921; P:glucocorticoid receptor signaling pathway; IEA:Compara.
 GO:0010766; P:negative regulation of sodium ion transport; IDA:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0010768; P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; IEA:Compara.
 GO:0007528; P:neuromuscular junction development; IMP:MGI.
 GO:0031175; P:neuron projection development; IEA:Compara.
 GO:0003151; P:outflow tract morphogenesis; IMP:MGI.
 GO:0046824; P:positive regulation of nucleocytoplasmic transport; IEA:Compara.
 GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IEA:Compara.
 GO:0045732; P:positive regulation of protein catabolic process; IDA:MGI.
 GO:0050847; P:progesterone receptor signaling pathway; IEA:Compara.
 GO:0006513; P:protein monoubiquitination; IDA:MGI.
 GO:0006622; P:protein targeting to lysosome; IEA:Compara.
 GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:MGI.
 GO:0032801; P:receptor catabolic process; IEA:Compara.
 GO:0031623; P:receptor internalization; IEA:Compara.
 GO:0042391; P:regulation of membrane potential; IEA:Compara.
 GO:1901016; P:regulation of potassium ion transmembrane transporter activity; IEA:Compara.
 GO:0050807; P:regulation of synapse organization; IMP:MGI.
 GO:0042110; P:T cell activation; IMP:MGI.
 GO:0019089; P:transmission of virus; IEA:Compara.
 GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:Compara. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR024928; E3_ub_ligase_SMURF1.
 IPR000569; HECT.
 IPR001202; WW_dom. 
Pfam
 PF00168; C2
 PF00632; HECT
 PF00397; WW 
SMART
 SM00239; C2
 SM00119; HECTc
 SM00456; WW 
PROSITE
 PS50004; C2
 PS50237; HECT
 PS01159; WW_DOMAIN_1
 PS50020; WW_DOMAIN_2 
PRINTS