UniProt Accession

 PP4R2_MOUSE; Q0VGB7; Q4G0D4; Q6P6N7; Q6PHU6; Q8BUU5 

Genbank Protein ID

 AK082539; BC056340; BC062117; BC098464; BC110429 

Genbank Nucleotide ID

 BAC38523.1; AAH56340.2; AAH62117.1; AAH98464.1; AAI10430.1 

Protein Name

 Serine/threonine-protein phosphatase 4 regulatory subunit 2 

Protein Synonyms/Alias

  

Gene Name

 Ppp4r2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
120	RNYTGTDKFLRGVEK	acetylation	[1]
229	VSLLSPVKNKHPDED	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair (By similarity). Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage- dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair (By similarity). 

Sequence Annotation

 MOD_RES 159 159 Phosphoserine.
 MOD_RES 226 226 Phosphoserine.
 MOD_RES 354 354 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; Cytoskeleton; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 417 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0030289; C:protein phosphatase 4 complex; ISS:UniProtKB.
 GO:0030362; F:protein phosphatase type 4 regulator activity; ISS:UniProtKB.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0010569; P:regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR015267; PPP4R2. 

Pfam

 PF09184; PPP4R2 

SMART

  

PROSITE

  

PRINTS