UniProt Accession

 YGFZ_ECOLI; P0ADE8; P39179; Q2M9U3; Q46826 

Genbank Protein ID

 U28375; U00096; AP009048 

Genbank Nucleotide ID

 AAA83079.1; AAC75936.1; BAE76963.1 

Protein Name

 tRNA-modifying protein YgfZ 

Protein Synonyms/Alias

  

Gene Name

 ygfZ 

Gene Synonyms/Alias

 yzzW; b2898; JW2866 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
66	LAAHCDAKGKMWSNL	acetylation	[1, 2]
68	AHCDAKGKMWSNLRL	acetylation	[2]
99	EPQLTELKKYAVFSK	acetylation	[2]
106	KKYAVFSKVTIAPDD	acetylation	[2]
139	LFSELPSKEKQVVKE	acetylation	[2]
176	TANMLTDKLRGEAEL	acetylation	[2]
268	AGEDLELKMGENWRR	acetylation	[2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication. 

Sequence Annotation

 BINDING 27 27 Folate (Potential).
 BINDING 189 189 Folate (Potential).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Folate-binding; Reference proteome; tRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 326 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004047; F:aminomethyltransferase activity; IEA:InterPro.
 GO:0005542; F:folic acid binding; IDA:EcoCyc.
 GO:0006546; P:glycine catabolic process; IEA:InterPro.
 GO:0009451; P:RNA modification; IEA:InterPro.
 GO:0008033; P:tRNA processing; IEA:HAMAP. 

Interpro

 IPR006222; GCV_T_N.
 IPR023758; tRNA-modifying_YgfZ.
 IPR017703; YgfZ/GcvT_CS. 

Pfam

 PF01571; GCV_T 

SMART

  

PROSITE

  

PRINTS