CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021006
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AP-3 complex subunit sigma-1 
Protein Synonyms/Alias
 AP-3 complex subunit sigma-3A; Adapter-related protein complex 3 sigma-1 subunit; Sigma-3A-adaptin; Sigma3A-adaptin; Sigma-adaptin 3a 
Gene Name
 Ap3s1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
18HGKPRLSKFYQPYSEubiquitination[1]
166ARAVSAVKNMNLPEIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. 
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasmic vesicle; Golgi apparatus; Membrane; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 193 AA 
Protein Sequence
MIKAILIFNN HGKPRLSKFY QPYSEDTQQQ IIRETFHLVS KRDENVCNFL EGGLLIGGSD 60
NKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC FENVCELDLI FHVDKVHNIL 120
AEMVMGGMVL ETNMNEIVTQ IDAQNKLEKS EAGLAGAPAR AVSAVKNMNL PEIPRNINIG 180
DISIKVPNLP SFK 193 
Gene Ontology
 GO:0030123; C:AP-3 adaptor complex; IEA:Compara.
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005802; C:trans-Golgi network; TAS:MGI.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0008089; P:anterograde axon cargo transport; IMP:UniProtKB.
 GO:0048490; P:anterograde synaptic vesicle transport; IMP:UniProtKB.
 GO:0006886; P:intracellular protein transport; TAS:MGI. 
Interpro
 IPR016635; AP_complex_ssu.
 IPR022775; AP_mu_sigma_su.
 IPR000804; Clathrin_sm-chain_CS.
 IPR011012; Longin-like_dom. 
Pfam
 PF01217; Clat_adaptor_s 
SMART
  
PROSITE
 PS00989; CLAT_ADAPTOR_S 
PRINTS