UniProt Accession

 SRY_HUMAN; Q05066 

Genbank Protein ID

 X53772; L10101; L10102; L08063; X96421; S53156; S56543; BC074923; BC074924 

Genbank Nucleotide ID

 CAA37790.1; AAA60590.1; AAA60591.1; AAA16878.1; CAA65281.1; AAB25008.1; AAB25716.1; AAH74923.1; AAH74924.1 

Protein Name

 Sex-determining region Y protein 

Protein Synonyms/Alias

 Testis-determining factor 

Gene Name

 SRY 

Gene Synonyms/Alias

 TDF 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
136	YRPRRKAKMLPKNCS	acetylation	[1]

Reference

 [1] Regulation of human SRY subcellular distribution by its acetylation/deacetylation.
 Thevenet L, Méjean C, Moniot B, Bonneaud N, Galéotti N, Aldrian-Herrada G, Poulat F, Berta P, Benkirane M, Boizet-Bonhoure B.
 EMBO J. 2004 Aug 18;23(16):3336-45. [PMID: 15297880] 

Functional Description

 Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. 

Sequence Annotation

 DNA_BIND 60 128 HMG box.
 REGION 59 136 Sufficient for interaction with KPNB1.
 REGION 61 77 Required for nuclear localization.
 REGION 107 139 Sufficient for interaction with EP300.
 REGION 130 136 Required for nuclear localization.
 REGION 138 155 Necessary for interaction with ZNF208
 REGION 198 204 Necessary for interaction with SLC9A3R2.
 MOD_RES 136 136 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Activator; ADP-ribosylation; Calmodulin-binding; Chromosomal rearrangement; Complete proteome; Cytoplasm; Differentiation; Disease mutation; DNA-binding; Nucleus; Reference proteome; Repressor; Sexual differentiation; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 204 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IDA:UniProtKB.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0030238; P:male sex determination; NAS:UniProtKB.
 GO:2000020; P:positive regulation of male gonad development; IDA:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0007548; P:sex differentiation; IEA:UniProtKB-KW. 

Interpro

 IPR009071; HMG_box_dom.
 IPR017253; TF_Sry. 

Pfam

 PF00505; HMG_box 

SMART

 SM00398; HMG 

PROSITE

 PS50118; HMG_BOX_2 

PRINTS