CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014770
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cell division cycle-associated protein 3 
Protein Synonyms/Alias
 Trigger of mitotic entry protein 1; TOME-1 
Gene Name
 Cdca3 
Gene Synonyms/Alias
 Tome1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
224TLTLRQGKRPSALSEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). 
Sequence Annotation
 REGION 90 124 F-box-like.
 MOTIF 263 265 KEN box.
 MOD_RES 204 204 Phosphoserine (By similarity).
 MOD_RES 207 207 Phosphothreonine (By similarity).
 MOD_RES 214 214 Phosphoserine (By similarity).  
Keyword
 Cell cycle; Cell division; Complete proteome; Cytoplasm; Mitosis; Phosphoprotein; Reference proteome; Ubl conjugation; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 273 AA 
Protein Sequence
MGSTQSVSGT PARPLPRNKH VSRVADPRSP SAGIQRTPIQ VESSPQPNPP AEQLNSLKQA 60
QDPDPRSPTL GIARTPMKIS GPDSQCPLVK ELSEVFETEV SETEVSESIS SPVLGLPQET 120
PLSSELDLPP DPDPQVSLED QLLPWSQTEL NSKQVFAKEE AKQSTETMVS GQTSDKPSRD 180
PETPQSSGSK RSRRKTNNKV LGRSPLTILQ DDNSPGTLTL RQGKRPSALS ENVKDLKEGV 240
ILGTGRFLKA GGGAWEQNED HDKENQHFAL MES 273 
Gene Ontology
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS