[1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
Functional Description
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).
Sequence Annotation
DOMAIN 31 88 Sushi. DOMAIN 103 345 Peptidase S1. REGION 259 264 Interaction with CD163 (By similarity). CARBOHYD 148 148 N-linked (GlcNAc...) (Potential). CARBOHYD 152 152 N-linked (GlcNAc...) (Potential). DISULFID 33 33 Interchain (By similarity). DISULFID 52 86 By similarity. DISULFID 90 207 Interchain (between alpha and beta DISULFID 250 281 By similarity. DISULFID 292 322 By similarity.
Keyword
Acute phase; Alternative splicing; Antibiotic; Antimicrobial; Antioxidant; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hemoglobin-binding; Immunity; Reference proteome; Secreted; Serine protease homolog; Signal; Sushi.