| Tag | Content |
|---|
| CPLM ID | CPLM-014717 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Autophagy-related protein 16-1 |
Protein Synonyms/Alias | APG16-like 1 |
Gene Name | ATG16L1 |
Gene Synonyms/Alias | APG16L; UNQ9393/PRO34307 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 513 | CSRDDLLKVIDLRTN | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. |
Sequence Annotation | REPEAT 320 359 WD 1.
REPEAT 364 403 WD 2.
REPEAT 406 445 WD 3.
REPEAT 447 484 WD 4.
REPEAT 486 525 WD 5.
REPEAT 532 573 WD 6.
REPEAT 575 607 WD 7.
MOD_RES 269 269 Phosphoserine.
MOD_RES 287 287 Phosphoserine.
MOD_RES 289 289 Phosphoserine (By similarity). |
Keyword | 3D-structure; Alternative splicing; Autophagy; Coiled coil; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Repeat; Transport; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 607 AA |
Protein Sequence | MSSGLRAADF PRWKRHISEQ LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS VLAQKLQAEK 60
HDVPNRHEIS PGHDGTWNDN QLQEMAQLRI KHQEELTELH KKRGELAQLV IDLNNQMQRK 120
DREMQMNEAK IAECLQTISD LETECLDLRT KLCDLERANQ TLKDEYDALQ ITFTALEGKL 180
RKTTEENQEL VTRWMAEKAQ EANRLNAENE KDSRRRQARL QKELAEAAKE PLPVEQDDDI 240
EVIVDETSDH TEETSPVRAI SRAATKRLSQ PAGGLLDSIT NIFGRRSVSS FPVPQDNVDT 300
HPGSGKEVRV PATALCVFDA HDGEVNAVQF SPGSRLLATG GMDRRVKLWE VFGEKCEFKG 360
SLSGSNAGIT SIEFDSAGSY LLAASNDFAS RIWTVDDYRL RHTLTGHSGK VLSAKFLLDN 420
ARIVSGSHDR TLKLWDLRSK VCIKTVFAGS SCNDIVCTEQ CVMSGHFDKK IRFWDIRSES 480
IVREMELLGK ITALDLNPER TELLSCSRDD LLKVIDLRTN AIKQTFSAPG FKCGSDWTRV 540
VFSPDGSYVA AGSAEGSLYI WSVLTGKVEK VLSKQHSSSI NAVAWSPSGS HVVSVDKGCK 600
AVLWAQY 607 |
Gene Ontology | GO:0005776; C:autophagic vacuole; ISS:UniProtKB. GO:0000421; C:autophagic vacuole membrane; IEA:Compara. GO:0034045; C:pre-autophagosomal structure membrane; IEA:UniProtKB-SubCell. GO:0000045; P:autophagic vacuole assembly; NAS:UniProtKB. GO:0051260; P:protein homooligomerization; NAS:UniProtKB. GO:0015031; P:protein transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |