CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011960
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear factor of activated T-cells, cytoplasmic 3 
Protein Synonyms/Alias
 NF-ATc3; NFATc3; NFATx; T-cell transcription factor NFAT4; NF-AT4 
Gene Name
 NFATC3 
Gene Synonyms/Alias
 NFAT4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
636SKIIFLEKGQDGRPQubiquitination[1]
649PQWEVEGKIIREKCQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2. 
Sequence Annotation
 REPEAT 207 223 1.
 REPEAT 236 252 2.
 REPEAT 292 308 3.
 DOMAIN 415 596 RHD.
 DNA_BIND 444 451
 REGION 109 114 Calcineurin-binding.
 REGION 207 308 3 X SP repeats.
 MOTIF 273 275 Nuclear localization signal.
 MOTIF 686 688 Nuclear localization signal.
 MOTIF 1032 1041 Nuclear export signal.
 MOD_RES 2 2 N-acetylthreonine.  
Keyword
 3D-structure; Acetylation; Activator; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1075 AA 
Protein Sequence
MTTANCGAHD ELDFKLVFGE DGAPAPPPPG SRPADLEPDD CASIYIFNVD PPPSTLTTPL 60
CLPHHGLPSH SSVLSPSFQL QSHKNYEGTC EIPESKYSPL GGPKPFECPS IQITSISPNC 120
HQELDAHEDD LQINDPEREF LERPSRDHLY LPLEPSYRES SLSPSPASSI SSRSWFSDAS 180
SCESLSHIYD DVDSELNEAA ARFTLGSPLT SPGGSPGGCP GEETWHQQYG LGHSLSPRQS 240
PCHSPRSSVT DENWLSPRPA SGPSSRPTSP CGKRRHSSAE VCYAGSLSPH HSPVPSPGHS 300
PRGSVTEDTW LNASVHGGSG LGPAVFPFQY CVETDIPLKT RKTSEDQAAI LPGKLELCSD 360
DQGSLSPARE TSIDDGLGSQ YPLKKDSCGD QFLSVPSPFT WSKPKPGHTP IFRTSSLPPL 420
DWPLPAHFGQ CELKIEVQPK THHRAHYETE GSRGAVKAST GGHPVVKLLG YNEKPINLQM 480
FIGTADDRYL RPHAFYQVHR ITGKTVATAS QEIIIASTKV LEIPLLPENN MSASIDCAGI 540
LKLRNSDIEL RKGETDIGRK NTRVRLVFRV HIPQPSGKVL SLQIASIPVE CSQRSAQELP 600
HIEKYSINSC SVNGGHEMVV TGSNFLPESK IIFLEKGQDG RPQWEVEGKI IREKCQGAHI 660
VLEVPPYHNP AVTAAVQVHF YLCNGKRKKS QSQRFTYTPG TRSHDGLL 708 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0045333; P:cellular respiration; IEA:Compara.
 GO:0071285; P:cellular response to lithium ion; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0006954; P:inflammatory response; TAS:ProtInc.
 GO:0055001; P:muscle cell development; IEA:Compara.
 GO:0001569; P:patterning of blood vessels; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0051145; P:smooth muscle cell differentiation; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. 
Interpro
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set.
 IPR002909; IPT_TIG_rcpt.
 IPR008366; NFAT.
 IPR008967; p53-like_TF_DNA-bd.
 IPR011539; RHD. 
Pfam
 PF00554; RHD 
SMART
 SM00429; IPT 
PROSITE
 PS01204; REL_1
 PS50254; REL_2 
PRINTS
 PR01789; NUCFACTORATC.