| Tag | Content |
|---|
| CPLM ID | CPLM-014582 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Actin-related protein 3B |
Protein Synonyms/Alias | ARP3-beta; Actin-like protein 3B |
Gene Name | Actr3b |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 230 | TAKAIKEKYCYICPD | ubiquitination | [1] | | 254 | VDPRKWIKQYTGINA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors (By similarity). |
Sequence Annotation | MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 244 244 N6-acetyllysine (By similarity).
MOD_RES 251 251 N6-acetyllysine (By similarity).
MOD_RES 254 254 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Actin-binding; Alternative splicing; ATP-binding; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Nucleotide-binding; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 418 AA |
Protein Sequence | MAGSLPPCVV DCGTGYTKLG YAGNTEPQFI IPSCIAIRES AKVVDQAQRR VLRGVDDLDF 60
FIGDEAIDKP TYATKWPIRH GIVEDWDLME RFMEQVVFKY LRAEPEDHYF LMTEPPLNTP 120
ENREYLAEIM FESFNVPGLY IAVQAVLALA ASWTSRQVGE RTLTGIVIDS GDGVTHVIPV 180
AEGYVIGSCI KHIPIAGRDI TYFIQQLLRE REVGIPPEQS LETAKAIKEK YCYICPDIVR 240
EFAKYDVDPR KWIKQYTGIN AINQKKFIID VGYERFLGPE IFFHPEFANP DFMESISDVV 300
DEVIQSCPID VRRPLYKNVV LSGGSTMFRD FGRRLQRDLK RVVDARLKLS QELSGGRIKP 360
KPVEVQVVTH HMQRYAVWFG GSMLASTPEF FQVCHTKKDY EEYGPSICRH NPVFGVMS 418 |
Gene Ontology | GO:0005885; C:Arp2/3 protein complex; IEA:InterPro. GO:0042995; C:cell projection; IEA:UniProtKB-SubCell. GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |