UniProt Accession

 DEOC_HUMAN; Q9Y315; Q53HN9; Q6PHW2 

Genbank Protein ID

 AF132960; AK222541; BC056234 

Genbank Nucleotide ID

 AAD27735.1; BAD96261.1; AAH56234.1 

Protein Name

 Putative deoxyribose-phosphate aldolase 

Protein Synonyms/Alias

 DERA; 2-deoxy-D-ribose 5-phosphate aldolase; Phosphodeoxyriboaldolase; Deoxyriboaldolase 

Gene Name

 DERA 

Gene Synonyms/Alias

 CGI-26 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
114	CDAVKALKAAGCNIP	ubiquitination	[1]
254	TGNKIGFKPAGGIRS	ubiquitination	[1]
263	AGGIRSAKDSLAWLS	ubiquitination	[2]
282	ELGDEWLKPELFRIG	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity). 

Sequence Annotation

 ACT_SITE 218 218 Schiff-base intermediate with
 ACT_SITE 254 254 By similarity.  

Keyword

 Complete proteome; Lyase; Reference proteome; Schiff base. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 318 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0004139; F:deoxyribose-phosphate aldolase activity; IDA:UniProtKB.
 GO:0046121; P:deoxyribonucleoside catabolic process; IDA:UniProtKB.
 GO:0009264; P:deoxyribonucleotide catabolic process; IEA:InterPro.
 GO:0046386; P:deoxyribose phosphate catabolic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR011343; DeoC.
 IPR002915; DeoC/FbaB/lacD_aldolase. 

Pfam

 PF01791; DeoC 

SMART

  

PROSITE

  

PRINTS