CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043639
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Triosephosphate isomerase 
Protein Synonyms/Alias
  
Gene Name
 Tpi1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
49VIACIGEKLDEREAGacetylation[1, 2]
60REAGITEKVVFEQTKacetylation[2, 3, 4]
60REAGITEKVVFEQTKsuccinylation[4]
60REAGITEKVVFEQTKubiquitination[5]
67KVVFEQTKVIADNVKacetylation[2, 3, 4]
67KVVFEQTKVIADNVKsuccinylation[4]
67KVVFEQTKVIADNVKubiquitination[5]
74KVIADNVKDWSKVVLacetylation[2, 4]
74KVIADNVKDWSKVVLsuccinylation[4]
74KVIADNVKDWSKVVLubiquitination[5]
78DNVKDWSKVVLAYEPacetylation[2]
78DNVKDWSKVVLAYEPubiquitination[5]
93VWAIGTGKTATPQQAacetylation[4]
93VWAIGTGKTATPQQAsuccinylation[4]
93VWAIGTGKTATPQQAubiquitination[5]
106QAQEVHEKLRGWLKSacetylation[1, 2, 4]
106QAQEVHEKLRGWLKSubiquitination[5]
112EKLRGWLKSNVNDGVacetylation[1, 2, 4, 6]
112EKLRGWLKSNVNDGVsuccinylation[4]
112EKLRGWLKSNVNDGVubiquitination[5]
156LVGGASLKPEFVDIIacetylation[1, 2, 3, 6]
156LVGGASLKPEFVDIIubiquitination[5]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [6] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Isomerase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 167 AA 
Protein Sequence
MIKDLGATWV VLGHSERRHV FGESDELIGQ KVSHALAEGL GVIACIGEKL DEREAGITEK 60
VVFEQTKVIA DNVKDWSKVV LAYEPVWAIG TGKTATPQQA QEVHEKLRGW LKSNVNDGVA 120
QSTRIIYGGS VTGATCKELA SQPDVDGFLV GGASLKPEFV DIINAKQ 167 
Gene Ontology
 GO:0004807; F:triose-phosphate isomerase activity; IDA:MGI.
 GO:0009790; P:embryo development; IMP:MGI.
 GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
 GO:0006006; P:glucose metabolic process; IDA:MGI.
 GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR000652; Triosephosphate_isomerase.
 IPR020861; Triosephosphate_isomerase_AS. 
Pfam
 PF00121; TIM 
SMART
  
PROSITE
 PS00171; TIM_1
 PS51440; TIM_2 
PRINTS