UniProt Accession

 PGFS_HUMAN; Q8TBF2; A8K793; B3KPY3; B4DQR9; B4E0S5; B7ZAC8; B9DI90; B9DI92; Q8N2H0 

Genbank Protein ID

 AK057027; AK075273; AK291908; AK298926; AK303504; AK316243; AF425266; AL139246; AL139246; AL139246; CH471183; CH471183; CH471183; BC022547 

Genbank Nucleotide ID

 BAG51845.1; BAC11511.1; BAF84597.1; BAG61031.1; BAG64537.1; BAH14614.1; AAP97295.1; CAX30825.1; CAX30826.1; CAX30827.1; EAW56086.1; EAW56087.1; EAW56088.1; AAH22547.1 

Protein Name

 Prostamide/prostaglandin F synthase 

Protein Synonyms/Alias

 Prostamide/PG F synthase; Prostamide/PGF synthase; Protein FAM213B 

Gene Name

 FAM213B 

Gene Synonyms/Alias

 C1orf93 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
101	DESKQLYKELGFKRY	ubiquitination	[1, 2]
120	ILPAALGKPVRDVAA	ubiquitination	[1, 2]
130	RDVAAKAKAVGIQGN	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity). 

Sequence Annotation

 MOD_RES 108 108 Phosphotyrosine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; NADP; Oxidoreductase; Phosphoprotein; Prostaglandin biosynthesis; Prostaglandin metabolism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 198 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; ISS:UniProtKB.
 GO:0019371; P:cyclooxygenase pathway; TAS:Reactome. 

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